Neutrophil Gelatinase-Associated Lipocalin and Retinol-Binding Protein-4 as Biomarkers for Diabetic Kidney Disease
Neutrophil Gelatinase-Associated Lipocalin and Retinol-Binding Protein-4 as Biomarkers for Diabetic Kidney Disease
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DOI：
10.1159/000505155
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发表时间：
2020-03-01
影响因子：
2.8
通讯作者：
Esteghamati, Alireza
中科院分区：
文献类型：
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作者：
Abbasi, Fatemeh;Moosaie, Fatemeh;Esteghamati, Alireza
目的：本研究旨在评价2种肾小管蛋白标志物（包括中性粒细胞明胶酶相关脂质运载蛋白（NGAL）和视黄醇结合蛋白-4（RBP-4））与蛋白尿和肾小球滤过率（GFR）之间的矛盾关系，并计算NGAL和RBP-4在2型糖尿病患者中诊断糖尿病肾病（DN）的准确性。方法：这是一项横断面研究，包括133例2型糖尿病患者。有3个糖尿病研究组，白蛋白尿正常，白蛋白尿中度增加，白蛋白尿严重增加，非糖尿病对照组无任何肾脏疾病。分析尿NGAL（uNGAL）和RBP-4在非糖尿病组与糖尿病组之间及糖尿病组内的差异。我们还评估了蛋白尿与NGAL和RBP-4之间的关系。结果如下：2型糖尿病患者尿NGAL和RBP-4水平高于非糖尿病患者，蛋白尿糖尿病患者尿NGAL和RBP-4水平高于非蛋白尿糖尿病患者（p值
Aims: This study was designed to evaluate the conflicting association between 2 tubular protein markers including neutrophil gelatinase-associated lipocalin (NGAL) and retinol-binding protein-4 (RBP-4) with albuminuria and glomerular filtration rate (GFR) and calculate the accuracy of the role of NGAL and RBP-4 in diagnosis of diabetic nephropathy (DN) in patients with type2 diabetes. Methods: This is a cross-sectional study that included 133 patients with type 2 diabetes. There were 3 diabetic study groups with normoalbuminuria, moderately increased albuminuria, severely increased albuminuria, and non-diabetic control group without any renal disease. We analyzed the difference of urinary NGAL (uNGAL) and RBP-4 between nondiabetics and diabetics, as well as within the diabetic group. We also assessed the association between albuminuria and NGAL and RBP-4. Results: The urinary levels of NGAL and RBP-4 were higher in patients with type 2 diabetes compared to nondiabetics as well as in albuminuric diabetics compared to nonalbuminuric patients with diabetes (p value