In vitro activities of DU-1102, a new trioxaquine derivative, against Plasmodium falciparum isolates
In vitro activities of DU-1102, a new trioxaquine derivative, against Plasmodium falciparum isolates
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DOI：
10.1128/aac.45.6.1886-1888.2001
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发表时间：
2001-06-01
影响因子：
4.9
通讯作者：
Meunier, B
中科院分区：
文献类型：
--
作者：
Basco, LK;Dechy-Cabaret, O;Meunier, B
由氨基喹啉和三氧环共价连接合成的抗疟三甲喹衍生物DU-1102对喀麦隆分离株恶性疟原虫具有较高的抗疟活性（平均50%抑制浓度为43 nmol/l）。对DU-1102的反应与氯喹的反应无相关性，对DU-1102的反应与乙胺嘧啶的反应相关性较低，表明三氯喹对寄生虫的作用模式是独立的。
The antimalarial trioxaquine derivative DU-1102, synthesized by covalent linkage between aminoquinoline and trioxane moieties, was highly active against Cameroonian isolates (mean 50% inhibitory concentration of 43 nmol/liter) of Plasmodium falciparum. There was no correlation between the responses to DU-1102 and chloroquine and only a low correlation between the responses to DU-1102 and pyrimethamine, suggesting an independent mode of action of the trioxaquine against the parasites.