Exposome: a new field, a new journal.
Exposome: a new field, a new journal.
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Exposome：一个新领域，一本新期刊。
DOI：
10.1093/exposome/osab001
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Miller,GaryW
中科院分区：
文献类型：
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作者：
Miller,GaryW
15年前，克里斯托弗·怀尔德（Christopher Wild）博士将“暴露”一词引入科学界，阐明了他对一个领域的愿景，即为基因组提供环境补充。在那篇影响深远的论文发表五年后，在建立一个暴露领域方面几乎没有进展，甚至没有手稿提到这个词。2010年之后，美国国家科学院举办了一个关于这一主题的研讨会，欧盟委员会呼吁建立研究中心。在接下来的十年里，我们见证了暴露学从原始的沼泽中慢慢爬出来，并开始演变成一门类似于科学学科或领域的东西。怀尔德博士将这段时期称为暴露者的“愤怒的青少年时期”。在过去的几年里，暴露体一直处于青春期，但这是一个困惑的青春期。与展览相关的项目和手稿在科学的荒野中漫无目的地游荡，这是我亲眼目睹的。这是流行病学的一部分吗？这是暴露科学吗？是毒理学吗？是生物学吗？是化学反应吗？是物理吗？这些在身份和科学方法上的斗争类似于托马斯·库恩在《科学革命的结构》中所描述的那种存在主义危机。4这种混乱和无序往往预示着某一学科或领域即将发生的变革。
Over 15 years ago, Dr. Christopher Wild introduced the word exposome to the scientific community, articulating his vision for a field that provided the environmental complement to the genome. Five years after that seminal publication there was little progress toward establishing an exposome field with no manuscripts even mentioning the word. After 2010, there was notably more activity with the US National Academy of Sciences hosting a workshop on the topic 2 and the European Commission issuing a call for research centers on the exposome. The following decade witnessed the exposome crawl from its primordial swamp and evolve into something that started to resemble a scientific discipline or field. Dr. Wild has referred to this as “the angry teenager years” for the exposome. The exposome has been in its adolescent stage for the past several years, but it has been a confused adolescence. Exposome-related projects and manuscripts wandered somewhat aimlessly in the scientific wilderness, something I have witnessed firsthand. 3 Is it part of epidemiology? Is it exposure science? Is it toxicology? Is it biology? Is it chemistry? Is it physics? These struggles in identity and scientific approaches parallel the sort of existential crisis described by Thomas Kuhn in The Structure of Scientific Revolutions. 4 The confusion and disorder often presage a pending transformation within a given discipline or field.