Sodium salicylate teratogenicity in vitro.
Sodium salicylate teratogenicity in vitro.
复制标题
水杨酸钠体外致畸性。
DOI：
10.1002/tera.1420260209
复制
发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Juchau,MR
中科院分区：
文献类型：
--
作者：
Greenaway,JC;Shepard,TH;Fantel,AG;Juchau,MR
大鼠胚胎暴露于水杨酸钠在体外浓度相当于那些用于产生畸胎在体内。将用400、600或800 μg水杨酸钠/ml处理的胚胎与用等摩尔浓度的NaCl处理的胚胎进行比较。与对照组相比，观察到生长参数呈显著剂量依赖性降低。以全身肿胀为特征的异常胚胎的发生率（特别是在菱脑区域）也具有剂量依赖性。本研究表明水杨酸盐在大鼠中的致畸性与母体因素无关。
Rat embryos were exposed to sodium salicylate in vitro at concentrations comparable to those used to produce terata in vivo. Embryos treated with 400, 600, or 800 μg Na salicylate/ml were compared with embryos treated with an equimolar concentration of NaCl. When compared to growth of the controls, a significant dose‐dependent decrease in growth parameters was observed. The incidence of abnormal embryos characterized by generalized swelling (particularly in the area of the rhombencephalon) was also dose dependent. This study demonstrates the teratogenicity of salicylate in the rat independent of maternal factors.