Integrating genetic and gene expression data to study the metabolic syndrome and diabetes in mice.
Integrating genetic and gene expression data to study the metabolic syndrome and diabetes in mice.
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DOI：
10.1097/01.mjt.0000178775.39149.64
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发表时间：
2005-11-01
影响因子：
4.2
通讯作者：
Lusis, Aldons J
中科院分区：
文献类型：
--
作者：
Drake, Thomas A;Schadt, Eric E;Lusis, Aldons J
小鼠正逐渐成为哺乳动物生理学和疾病的标准模型。它可以相对容易地进行基因分析和操纵。此外，存在于近交系小鼠品系中的内源性遗传变异可用于鉴定涉及糖尿病和代谢综合征以及与人类疾病相关的其他病症的复杂生理过程的遗传控制。遗传学和基因表达技术的最新进展大大增加了从这种方法中获得的知识，当应用于传统的遗传学研究时。
Increasingly, the mouse is becoming the standard model for mammalian physiology and disease. It can be genetically analyzed and manipulated with relative ease. Moreover, the endogenous genetic variation that exists among inbred mouse strains can be exploited to identify genetic control of complex physiologic processes involved in diabetes and the metabolic syndrome, among other conditions relevant to human disease. Recent advances in genetics and gene expression technology have greatly increased the knowledge to be derived from this approach when applied to traditional genetic studies.