A twist in anti-inflammation:: Annexin 1 acts via the lipoxin A4 receptor
A twist in anti-inflammation:: Annexin 1 acts via the lipoxin A4 receptor
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DOI：
10.1016/j.plefa.2005.05.008
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发表时间：
2005-09-01
影响因子：
3
通讯作者：
Perretti, M
中科院分区：
文献类型：
--
作者：
Gavins, FNE;Sawmynaden, P;Perretti, M
炎症反应是身体为克服病原体感染和损伤而设置的拯救生命的保护过程;然而，在慢性炎症病理中，这种反应可能变得失调。现在已经出现了在体内运作以下调炎症的专门抗炎途径/介质的存在。因此，导致病理学的炎症持续存在可能是由于一种或多种反调节途径发生故障造成的。在这里，我们专注于其中之一，抗炎介质膜联蛋白1，并提供了最新的白细胞运输过程中的抑制作用。特别是，最近的证据表明，甲酰肽家族的受体，也包括脂氧素A（4）受体，可能是膜联蛋白1受体的背景下，抗炎可能提供新的途径，利用这一途径的药物发现。(c)2005爱思唯尔有限公司保留所有权利。
The inflammatory response is a life-saving protective process mounted by the body to overcome pathogen infection and injury; however, in chronic inflammatory pathologies this response can become deregulated. The existence of specialized anti-inflammatory pathways/mediators that operate in the body to down-regulate inflammation have now emerged. Thus, persistence of inflammation leading to pathology could be due to malfunctioning of one or more of these counter-regulatory pathways. Here we focus on one of them, the anti-inflammatory mediator annexin 1, and provide an update on its inhibitory effects upon the leukocyte trafficking process. In particular, recent evidence that receptors of the formyl-peptide family, which includes also the lipoxin A(4) receptor, could be the annexin 1 receptor(s) in the context of anti-inflammation might provide new avenues for exploiting this pathway for drug discovery. (c) 2005 Elsevier Ltd. All rights reserved.