Intensive local thermotherapy cleared extensive viral warts in a patient with systemic lupus erythematosus
Intensive local thermotherapy cleared extensive viral warts in a patient with systemic lupus erythematosus
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DOI：
10.3109/02656736.2014.993339
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发表时间：
2015-01
影响因子：
3.1
通讯作者：
Yi Ren;W. Huo;Rui-Qun Qi;Lanting Hu;Xing-Hua Gao
中科院分区：
文献类型：
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作者：
Yi Ren;W. Huo;Rui-Qun Qi;Lanting Hu;Xing-Hua Gao
摘要目的：各种药物和程序可用于治疗疣，但似乎在系统性红斑狼疮（SLE）患者的治疗反应很差。有必要探讨局部热疗治疗广泛性病毒性疣的可行性、安全性和有效性。材料与方法：一位全身性类固醇激素治疗的SLE患者，在她的双手和双脚上出现了广泛的病毒性疣，持续数月。她的SLE疾病活动指数（SLEDAI）评分很高，高达30分，并广泛接受高剂量和长时间皮质类固醇治疗，并间歇使用环磷酰胺。我们在第1、2、3、17、18天对靶病变应用44 °C的局部热疗30分钟，该方案已成功用于治疗病毒性疣。在3个月的随访中没有临床反应的迹象。然后我们按照每周一次的方案治疗病人。结果：10周内病灶全部清除，无复发.结论：本观察结果提示，更强烈的局部热疗是清除SLE病毒疣所必需的。
Abstract Purpose: A variety of medications and procedures are available for the treatment of warts, but it appeared the treatment response in systemic lupus erythematosus (SLE) patients is poor. It is necessary to investigate the feasibility, safety and efficacy of local thermotherapy for extensive viral warts. Materials and methods: A SLE patient on systemic steroid developed extensive viral warts on both her hands and feet for months. She had a high score of SLE Disease Activity Index (SLEDAI), up to 30, and was extensively treated with high and prolonged dosage of corticosteroid and intermittent use of cyclophosphamide. We applied local hyperthermia at 44 °C on a target lesion for 30 min on days 1, 2, 3, 17, 18, a protocol which has been successfully used in treating viral warts. There was no sign of clinical response in a 3-month follow-up. Then we treated the patient on a once-a-week protocol. Result: All the lesions cleared in ten weeks and there was no sign of recurrence. Conclusion: This observation suggests that more intensive local hyperthermia is required for clearing viral warts in SLE.