Time-Shift Homotopic Connectivity in Mesial Temporal Lobe Epilepsy
Time-Shift Homotopic Connectivity in Mesial Temporal Lobe Epilepsy
复制标题
内侧颞叶癫痫的时移同位连接
DOI：
10.3174/ajnr.a3934
复制
发表时间：
2014-09-01
影响因子：
3.5
通讯作者：
Lu, G.
中科院分区：
文献类型：
--
作者：
Xu, Q.;Zhang, Z.;Lu, G.
背景和目的：体素镜像内在功能连接允许描述人脑中半球间的同伦连接，而时移内在功能连接允许通过测量血流动力学特性来检测脑损伤的程度。我们结合时移体素镜像同伦连接分析来研究内侧颞叶癫痫同伦连接的变化，并评估将该方法应用于癫痫偏侧化和预测内侧颞叶癫痫手术结果的价值。材料和方法：静息态功能 MR 成像数据来自单侧内侧颞叶癫痫患者 (n = 62)（左侧 31 例，右侧 31 例）和健康对照 (n = 33)。通过 0、1、2 和 3 次重复时间时移体素镜像同伦连接单独计算来自每个半球的动态半球间同伦结构。通过对每个时移条件分别使用单向方差分析，比较患者组和对照组之间的体素镜像同伦连接图。进一步对每个时移条件下体素镜像同伦连接的偏侧性进行组比较。最后，我们将半球间同伦联系与部分患者 (n = 20) 的手术结果相关联。结果：内侧颞叶癫痫患者表现出内侧颞叶结构、颞极和纹状体的同伦连接性降低。双半球同伦连接的改变随着内侧颞叶癫痫的时移延迟而偏侧化。手术结果不成功的患者表现出较大的半球间体素镜像同伦连接差异。结论：这项研究显示了内侧颞叶癫痫中半球间同伦连接动态改变的整体模式，扩展了对该疾病中半球间连接异常的认识。时移体素镜像同伦连接具有单侧内侧颞叶癫痫偏侧化的潜力，并且可能具有预测这种情况下的手术结果的能力。
BACKGROUND AND PURPOSE: Voxel-mirrored intrinsic functional connectivity allows the depiction of interhemispheric homotopic connections in the human brain, whereas time-shift intrinsic functional connectivity allows the detection of the extent of brain injury by measuring hemodynamic properties. We combined time-shift voxel-mirrored homotopic connectivity analyses to investigate the alterations in homotopic connectivity in mesial temporal lobe epilepsy and assessed the value of applying this approach to epilepsy lateralization and the prediction of surgical outcomes in mesial temporal lobe epilepsy. MATERIALS AND METHODS: Resting-state functional MR imaging data were acquired from patients with unilateral mesial temporal lobe epilepsy (n = 62) (31 left- and 31 right-side) and healthy controls (n = 33). Dynamic interhemispheric homotopic architecture seeding from each hemisphere was individually calculated by 0, 1, 2, and 3 repetition time time-shift voxel-mirrored homotopic connectivity. Voxel-mirrored homotopic connectivity maps were compared between the patient and control groups by using 1-way ANOVA for each time-shift condition, separately. Group comparisons were further performed on the laterality of voxel-mirrored homotopic connectivity in each time-shift condition. Finally, we correlated the interhemispheric homotopic connection to the surgical outcomes in a portion of the patients (n = 20). RESULTS: The patients with mesial temporal lobe epilepsy showed decreased homotopic connectivity in the mesial temporal structures, temporal pole, and striatum. Alterations of the bihemispheric homotopic connectivity were lateralized along with delays in the time-shift in mesial temporal lobe epilepsy. The patients with unsuccessful surgical outcomes presented larger interhemispheric voxel-mirrored homotopic connectivity differences. CONCLUSIONS: This study showed whole patterns of dynamic alterations of interhemispheric homotopic connectivity in mesial temporal lobe epilepsy, extending the knowledge of abnormalities in interhemispheric connectivity in this condition. Time-shift voxel-mirrored homotopic connectivity has the potential for lateralization of unilateral mesial temporal lobe epilepsy and may have the capability of predicting surgical outcomes in this condition.