Symptoms and subjective quality of life in post-traumatic stress disorder: a longitudinal study.

Symptoms and subjective quality of life in post-traumatic stress disorder: a longitudinal study.
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DOI:
10.1371/journal.pone.0060991
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发表时间:
2013
期刊:
影响因子:
3.7
通讯作者:
Priebe S
Priebe S
中科院分区:
综合性期刊3区
文献类型:
--
作者:
Giacco D;Matanov A;Priebe S

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有证据表明,创伤后应激障碍(PTSD)与主观生活质量(SQOL)大幅下降有关。本研究旨在探讨创伤后应激障碍症状群的侵入、回避和过度觉醒水平的变化是否以及如何与SQOL的变化相关。研究了两个在前南斯拉夫战争后患有PTSD的样本,即来自五个巴尔干半岛的国家的530人的代表性样本和来自三个西欧国家的215名难民的非代表性样本。他们在战后平均八年接受评估,一年后再次接受采访。PTSD症状采用修订的事件量表和曼彻斯特生活质量短期评估的SQOL进行评估。采用线性回归和两波交叉滞后面板分析探讨PTSD症状群与SQOL的关系。两个样本的结果是一致的。随着时间的推移,症状减轻与SQOL改善相关。在多变量分析中,调整了所有三个聚类、性别和战争暴露时间的影响,只有过度觉醒症状的变化与SQOL的变化显著相关。双波交叉滞后面板分析表明,过度觉醒症状和SQOL之间的联系是双向的。战争相关PTSD患者的低SQOL与过度觉醒症状特别相关。研究结果表明存在双向影响:过度觉醒症状的减少可能会导致SQOL的改善,而SQOL的改善可能会导致过度觉醒症状的减少。
Evidence suggests that post-traumatic stress disorder (PTSD) is associated with substantially reduced subjective quality of life (SQOL). This study aimed to explore whether and how changes in the levels of PTSD symptom clusters of intrusion, avoidance and hyperarousal are associated with changes in SQOL. Two samples with PTSD following the war in former Yugoslavia were studied, i.e. a representative sample of 530 people in five Balkan countries and a non-representative sample of 215 refugees in three Western European countries. They were assessed on average eight years after the war and re-interviewed one year later. PTSD symptoms were assessed on the Impact of Event Scale - Revised and SQOL on the Manchester Short Assessment of Quality of Life. Linear regression and a two-wave cross lagged panel analysis were used to explore the association between PTSD symptom clusters and SQOL. The findings in the two samples were consistent. Symptom reduction over time was associated with improved SQOL. In multivariable analyses adjusted for the influence of all three clusters, gender and time since war exposure, only changes in hyperarousal symptoms were significantly associated with changes in SQOL. The two-wave cross-lagged panel analysis suggested that the link between hyperarousal symptoms and SQOL is bidirectional. Low SQOL of patients with war-related PTSD is particularly associated with hyperarousal symptoms. The findings suggest a bidirectional influence: a reduction in hyperarousal symptoms may result in improved SQOL, and improvements in SQOL may lead to reduced hyperarousal symptoms.
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