CLONUS - THE ROLE OF CENTRAL MECHANISMS
CLONUS - THE ROLE OF CENTRAL MECHANISMS
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DOI：
10.1136/jnnp.43.4.321
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发表时间：
1980-01-01
影响因子：
11
通讯作者：
SHERWOOD, AM
中科院分区：
文献类型：
--
作者：
DIMITRIJEVIC, MR;NATHAN, PW;SHERWOOD, AM
研究了人持续性肺炎的外周和中枢成分。阵挛通常出现在神经系统疾病中，仅当病变累及外侧皮质脊髓束纤维时才会出现。通过敲击肌腱、振动刺激序列和h反射传入齐射来检测运动神经元对clonus持续拉伸的兴奋性。运动神经元的每一次阵挛放电之后都有一个不应期，不应期之后是一个较短的兴奋期。在不应期后，运动神经元的兴奋性恢复之前，它们对连续拉伸的克隆性反应不能作出反应。用各种方法改变克隆率的尝试都失败了。通过以1-15 Hz的频率反复敲击肌腱，研究了是否运动神经元倾向于以阵挛的速率对其他Ia截击作出最大反应。有一个最大的反应在速度的克隆。除拉伸引起的皮肤输入外，其他皮肤输入可引起冠状胬肉。
The peripheral and central components in sustained clonus in humans were investigated. Clonus is usually present in neurological disorders, and arises only when there is a lesion involving lateral corticospinal tract fibers. The excitability of the motoneurons responding to maintained stretch by clonus was examined by tendon taps, trains of vibratory stimuli and H-reflex afferent volleys. Every burst of clonic discharge of the motoneurons was followed by a refractory period, which was followed by a shorter excitatory period. The motoneurons responding clonically to a continuous stretch cannot respond until their excitability is regained after the refractory period. Attempts to change the rate of clonus in various ways failed. Whether motoneurons of clonic muscles tend to respond maximally to other Ia volleys at the rate of clonus was examined by applying repeated taps to the tendon at rates from 1-15 Hz. There was a maximal response at the rate of clonus. Cutaneous inputs other than those induced by stretch cause clonus.