2nd Australia–China Biomedical Research Conference (ACBRC2009) New strategies for cancer gene therapy: Progress and opportunities
2nd Australia–China Biomedical Research Conference (ACBRC2009) New strategies for cancer gene therapy: Progress and opportunities
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发表时间：
2009
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通讯作者：
Siyu Cao;A. Cripps;Ming QWei
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作者：
Siyu Cao;A. Cripps;Ming QWei
1.迄今为止，癌症仍然是世界上最具破坏性的疾病之一。诸如转移和肿瘤对化学疗法和放射疗法的抗性的问题严重限制了现有临床治疗的治疗效果。2.为了解决这些问题，癌症基因治疗在过去二十年中一直在发展，专门设计用于使用载体系统递送治疗性基因以治疗癌症。到目前为止，许多基因和运载工具已被评估，并取得了重大进展，在临床试验中的几个基因治疗模式。然而，缺乏理想的基因递送系统仍然是将方案成功转化为临床的主要障碍。3.近年来对实体瘤内缺氧和坏死区域的了解以及重组DNA技术的快速发展重新激发了使用厌氧菌作为新型基因递送系统的想法。这些细菌载体与其他载体相比具有独特的优势，有可能在不久的将来成为癌症基因治疗的首选载体。4.同时，复杂的肿瘤病理生理学和相关的转移使得很难依靠单一的治疗方式来完全根除肿瘤。因此，癌症基因治疗与其他常规治疗的结合已变得至关重要。5.本文综述了近年来肿瘤基因治疗的研究进展，重点介绍了细菌介导的肿瘤基因治疗。此外，示例性的组合疗法进行了简要回顾。
1. To date, cancer persists as one of the most devastating diseases worldwide. Problems such as metastasis and tumour resistance to chemotherapy and radiotherapy have seriously limited the therapeutic effects of existing clinical treatments. 2. To address these problems, cancer gene therapy has been developing over the past two decades, specifically designed to deliver therapeutic genes to treat cancers using vector systems. So far, a number of genes and delivery vehicles have been evaluated and significant progress has been made with several gene therapy modalities in clinical trials. However, the lack of an ideal gene delivery system remains a major obstacle for the successful translation of regimen to the clinic. 3. Recent understanding of hypoxic and necrotic regions within solid tumours and rapid development of recombinant DNA technology have reignited the idea of using anaerobic bacteria as novel gene delivery systems. These bacterial vectors have unique advantages over other delivery systems and are likely to become the vector of choice for cancer gene therapy in the near future. 4. Meanwhile, complicated tumour pathophysiology and associated metastasis make it hard to rely on a single therapeutic modality for complete tumour eradication. Therefore, the combination of cancer gene therapy with other conventional treatments has become paramount. 5. The present review introduces important cancer gene therapy strategies and major vector systems that have been studied so far with an emphasis on bacteria-mediated cancer gene therapy. In addition, exemplary combined therapies are briefly reviewed.