Genomic sequence of hst, a transforming gene encoding a protein homologous to fibroblast growth factors and the int-2-encoded protein.
Genomic sequence of hst, a transforming gene encoding a protein homologous to fibroblast growth factors and the int-2-encoded protein.
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hst 的基因组序列，hst 是一种转化基因，编码与成纤维细胞生长因子同源的蛋白质和 int-2 编码的蛋白质。
DOI：
10.1073/pnas.84.20.7305
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发表时间：
1987
影响因子：
11.1
通讯作者：
Takashi Sugimura
中科院分区：
文献类型：
--
作者：
T. Yoshida;K. Miyagawa;H. Odagiri;H. Sakamoto;P. Little;M. Terada;Takashi Sugimura
hst is a transforming gene first identified from transformed NIH 3T3 cells that were transfected with DNA of a human stomach cancer. A genomic fragment of hst obtained directly from a human genomic library also has transforming activity. This fragment has a coding sequence identical to that of the hst cDNA prepared from an NIH 3T3 transformant induced by DNA from a stomach cancer. The deduced amino acid sequence of the hst protein is 43%, 38%, and 40% homologous, respectively, to human basic fibroblast growth factor, human acidic fibroblast growth factor, and mouse int-2 protein in selected regions. This suggests that hst encodes a protein related to fibroblast growth factors, which are wide-spectrum mitogens, and to the int-2 protein, a potential oncogene product implicated in murine mammary carcinogenesis.
