Radical Carboxylation: Ester Synthesis from Alkyl Iodides, Carbon Monoxide, and Alcohols under Irradiation Conditions
Radical Carboxylation: Ester Synthesis from Alkyl Iodides, Carbon Monoxide, and Alcohols under Irradiation Conditions
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DOI：
10.1021/ja964124g
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发表时间：
1997-06
影响因子：
15
通讯作者：
K. Nagahara;I. Ryu;M. Komatsu;N. Sonoda
中科院分区：
文献类型：
--
作者：
K. Nagahara;I. Ryu;M. Komatsu;N. Sonoda
毫无疑问，过渡金属催化的有机卤化物与CO的羰基化得到羧酸及其衍生物是一种基本和重要的合成方法（方程式1）。1，2众所周知，孟山都化学公司从甲醇和CO生产乙酸，该工艺的关键步骤涉及Rh催化的甲基碘羰基化生成乙酰碘。3然而，在本文中，我们报道了一种概念上的新方法，用于从烷基碘、醇和CO的组合合成羧酸酯，该方法可以在没有金属催化剂的情况下用光照射进行（等式2）。4在我们以前的论文中，我们报道了通过光解
There is little doubt that transition metal-catalyzed carbonylation of organic halides with CO to give carboxylic acids and their derivatives is a basic and important synthetic process (eq 1). 1, 2 It is well-known that the Monsanto Chemical Company produces acetic acid from methanol and CO and that a key step in this process involves the Rh-catalyzed carbonylation of methyl iodide to give acetyl iodide. 3 In this paper, however, we report a conceptually new method for the synthesis of carboxylic acid esters from the combination of alkyl iodides, alcohols, and CO that can be carried out with photoirradiation in the absence of a metal catalyst (eq 2). 4 In our previous paper, we reported the synthesis of acyl selenides by the photolysis of