Increased spinal dynorphin contributes to chronic nicotine-induced mechanical hypersensitivity in the rat
Increased spinal dynorphin contributes to chronic nicotine-induced mechanical hypersensitivity in the rat
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DOI：
10.1016/j.neulet.2007.06.002
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发表时间：
2007-07-05
影响因子：
2.5
通讯作者：
Vincler, Michelle
中科院分区：
文献类型：
--
作者：
Lough, Chris;Young, Tracey;Vincler, Michelle
既往研究表明，长期给予尼古丁可在大鼠中产生机械超敏反应，但这种作用的机制尚不清楚。长期全身给予尼古丁3.6或8.6 mg/（kg/天）14-21天的大鼠表现出机械超敏反应，与脊髓内强啡肽原免疫反应性和强啡肽含量增加一致。鞘内注射强啡肽抗血清可显著减弱慢性尼古丁诱导的机械超敏反应。我们的研究结果表明，慢性尼古丁给药产生脊髓强啡肽含量和释放的增加，有助于机械超敏反应。(c)2007爱思唯尔爱尔兰有限公司保留所有权利。
Chronic nicotine administration has been shown previously to produce mechanical hypersensitivity in the rat although the mechanism of this effect is unknown. Rats treated with chronic systemic nicotine 3.6 or 8.6 mg/(kg day) for 14-21 days displayed mechanical hypersensitivity coincident with an increase of prodynorphin immunoreactivity and dynorphin content within the spinal cord. The administration of dynorphin antiserum intrathecally significantly attenuated chronic nicotine-induced mechanical hypersensitivity. Our results suggest that chronic nicotine administration produces an increase in spinal dynorphin content and release that contributes to mechanical hypersensitivity. (c) 2007 Elsevier Ireland Ltd. All rights reserved.