Higher dietary intake of alpha-linolenic acid is associated with lower insulin resistance in middle-aged Japanese
Higher dietary intake of alpha-linolenic acid is associated with lower insulin resistance in middle-aged Japanese
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DOI：
10.1016/j.ypmed.2010.02.014
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发表时间：
2010-05-01
影响因子：
5.1
通讯作者：
Tamakoshi, Koji
中科院分区：
文献类型：
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作者：
Muramatsu, Takashi;Yatsuya, Hiroshi;Tamakoshi, Koji
Objective.研究n-3多不饱和脂肪酸（植物来源的α-亚麻酸：ALA，海洋来源的二十碳五烯酸和二十二碳六烯酸：EPA + DHA）的膳食摄入量与高n-3 PUFA摄入量的瘦人群的胰岛素抵抗（IR）之间的关系。我们在2002年对3383名年龄在35-66岁的日本地方政府工作人员进行了横断面研究。IR被定义为稳态模型评估的最高四分位数，营养素摄入量通过饮食史问卷进行估计。以ALA或EPA + DHA摄入量的最低四分位数为参照，进行Logistic回归分析，计算IR的OR值。平均年龄、体重指数（BMI）、膳食ALA和膳食EPA + DHA的中位数分别为47.9岁、22.9 kg/m2、1.90 g/d（0.88%E）和0.77 g/d（0.36%E）。在ALA摄入量的四分位数中，IR的OR降低（Q4与Q1的多变量校正OR = 0.74，趋势P = 0.01），仅在BMI <
Objective. To investigate the associations between dietary intake of n-3 polyunsaturated fatty acids (plant-derived alpha-linolenic acid: ALA, and marine-derived eicosapentaenoic and docosahexaenoic acid: EPA + DHA) and insulin resistance (IR) in a lean population with high n-3 PUFA intake.Method. We cross-sectionally studied 3383 Japanese local government workers aged 35-66 in 2002. IR was defined as the highest quartile of homeostasis model assessment, and nutrient intake was estimated from a diet history questionnaire. The odds ratios (ORs) of IR taking the lowest quartile of ALA or EPA + DHA intake as the reference were calculated by logistic regression analysis.Results. Mean age, body mass index (BMI), and dietary ALA, and median of dietary EPA + DHA were 47.9 years, 22.9 kg/m(2), and 1.90 g/day (0.88%E) and 0.77 g/day (0.36%E), respectively. The ORs of IR decreased across the quartiles of ALA intake (multivariate-adjusted OR for Q4 versus Q1 = 0.74, P for trend = 0.01) and the association was observed only in subjects with a BMI of