Circadian clock: linking epigenetics to aging.
Circadian clock: linking epigenetics to aging.
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DOI：
10.1016/j.gde.2014.06.003
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发表时间：
2014-06
影响因子：
4
通讯作者：
Sassone-Corsi P
中科院分区：
文献类型：
--
作者：
Orozco-Solis R;Sassone-Corsi P
昼夜节律是由控制大量生理和代谢过程的内在细胞机制产生的。在衰老过程中，昼夜节律的稳健性受到侵蚀，特定基因的遗传消融对生物钟的破坏与衰老相关的特征有关。重要的是，环境条件被认为可以调节衰老过程。例如，热量限制是一个非常强大的环境效应器，能够延缓衰老。涉及营养传感器的细胞内途径，如SIRTs和mTOR复合物，影响控制衰老过程的细胞和表观遗传机制。引人注目的是，越来越多的证据表明，这些通路参与了衰老过程的调节和生物钟的控制。因此，专注于控制生物钟和营养感应途径的创新治疗策略可能会有益地影响衰老的负面影响。
Circadian rhythms are generated by an intrinsic cellular mechanism that controls a large array of physiological and metabolic processes. There is erosion in the robustness of circadian rhythms during aging, and disruption of the clock by genetic ablation of specific genes is associated with aging-related features. Importantly, environmental conditions are thought to modulate the aging process. For example, caloric restriction is a very strong environmental effector capable of delaying aging. Intracellular pathways implicating nutrient sensors, such as SIRTs and mTOR complexes, impinge on cellular and epigenetic mechanisms that control the aging process. Strikingly, accumulating evidences indicate that these pathways are involved in both the modulation of the aging process and the control of the clock. Hence, innovative therapeutic strategies focused at controlling the circadian clock and the nutrient sensing pathways might beneficially influence the negative effects of aging.