The Role of Dopamine and Its Dysfunction as a Consequence of Oxidative Stress.
The Role of Dopamine and Its Dysfunction as a Consequence of Oxidative Stress.
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DOI：
10.1155/2016/9730467
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发表时间：
2016
影响因子：
--
通讯作者：
Barragán Mejía G
中科院分区：
文献类型：
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作者：
Juárez Olguín H;Calderón Guzmán D;Hernández García E;Barragán Mejía G
多巴胺是一种神经递质，产生于大脑的黑质、腹侧被盖区和下丘脑。多巴胺系统的功能障碍与不同的神经系统疾病有关。多巴胺传递水平的增加是对任何类型的奖励的反应，也是对大量强加成药物的反应。多巴胺功能障碍作为氧化应激的结果的作用涉及健康和疾病。引入新的潜在目标，以开发基于抗氧化剂化合物的治疗干预措施。本文综述了抗氧化化合物作为常规神经系统疾病辅助治疗的治疗潜力。
Dopamine is a neurotransmitter that is produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain. Dysfunction of the dopamine system has been implicated in different nervous system diseases. The level of dopamine transmission increases in response to any type of reward and by a large number of strongly additive drugs. The role of dopamine dysfunction as a consequence of oxidative stress is involved in health and disease. Introduce new potential targets for the development of therapeutic interventions based on antioxidant compounds. The present review focuses on the therapeutic potential of antioxidant compounds as a coadjuvant treatment to conventional neurological disorders is discussed.