Biomarkers of mitochondrial dysfunction and inflammaging in older adults and blood pressure variability
Biomarkers of mitochondrial dysfunction and inflammaging in older adults and blood pressure variability
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DOI：
10.1007/s11357-022-00697-y
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发表时间：
2022-12-01
期刊：
影响因子：
5.6
通讯作者：
Rouch, Laure
中科院分区：
文献类型：
--
作者：
Bencivenga, Leonardo;Strumia, Mathilde;Rouch, Laure
血压变异性（BPV）的大多数生理病理机制都与衰老有关。血管老化与晚年发生的慢性低度炎症有关，这种炎症被称为“炎症”，是由年龄相关压力引起的标志性“线粒体功能障碍”。我们的目的是确定多效性应激相关的分裂因子生长/分化因子15 （GDF-15）和两种炎症生物标志物，白细胞介素6 （IL-6）和肿瘤坏死因子受体1 （TNFR-1）的血浆水平是否与社区居住老年人的来访BPV相关。研究人群包括1096名社区居民[中位年龄75（72-78）岁；699名女性（63.7%）年龄为70岁，来自MAPT研究。入组12个月后采集血浆血样，在4年期间评估血压达7次。收缩压（SBPV）和舒张压（DBPV）是通过几个指标来确定的，这些指标考虑了血压随时间的变化、测量顺序和独立于平均血压水平的公式。调整相关协变量后，较高的GDF-15值与SBPV（所有指标）的增加显著相关[调整后的1-SD GDF-15增加：β (SE) = 0.07 (0.04), p < 0.044，变异系数%]。GDF-15水平与DBPV无关。IL-6与BPV之间未发现显著相关性，而TNFR1仅与DBPV部分相关。与炎症生物标志物不同，较高的GDF-15水平与较高的SBPV相关。我们的研究结果支持年龄相关的线粒体功能障碍过程是血压不稳定的基础，表明BPV可能是衰老的潜在标志。
Most physiopathological mechanisms underlying blood pressure variability (BPV) are implicated in aging. Vascular aging is associated with chronic low-grade inflammation occurring in late life, known as "inflammaging " and the hallmark "mitochondrial dysfunction " due to age-related stress. We aimed to determine whether plasma levels of the pleiotropic stress-related mitokine growth/differentiation factor 15 (GDF-15) and two inflammatory biomarkers, interleukin 6 (IL-6) and tumor necrosis factor receptor 1 (TNFR-1), are associated with visit-to-visit BPV in a population of community-dwelling older adults. The study population consisted of 1096 community-dwelling participants [median age 75 (72-78) years; 699 females, 63.7%] aged >= 70 years from the MAPT study. Plasma blood sample was collected 12 months after enrolment and BP was assessed up to seven times over a 4-year period. Systolic (SBPV) and diastolic BPV (DBPV) were determined through several indicators taking into account BP change over time, the order of measurements and formulas independent of mean BP levels. Higher values of GDF-15 were significantly associated with increased SBPV (all indicators) after adjustment for relevant covariates [adjusted 1-SD increase in GDF-15: beta (SE) = 0.07 (0.04), p < 0.044, for coefficient of variation%]. GDF-15 levels were not associated with DBPV. No significant associations were found between IL-6 and BPV, whereas TNFR1 was only partially related to DBPV. Unlike inflammation biomarkers, higher GDF-15 levels were associated with greater SBPV. Our findings support the age-related process of mitochondrial dysfunction underlying BP instability, suggesting that BPV might be a potential marker of aging.