Associations of NADPH oxidase-related genes with blood pressure changes and incident hypertension: The GenSalt Study.
Associations of NADPH oxidase-related genes with blood pressure changes and incident hypertension: The GenSalt Study.
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NADPH 氧化酶相关基因与血压变化和高血压事件的关联：GenSalt 研究
DOI：
10.1038/s41371-018-0041-6
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发表时间：
2018-04
影响因子：
2.7
通讯作者：
Chen S
中科院分区：
文献类型：
--
作者：
Li H;Han X;Hu Z;Huang J;Chen J;Hixson JE;Rao DC;He J;Gu D;Chen S
既往研究表明，NADPH氧化酶（Nox）产生的活性氧是高血压的重要危险因素。本研究旨在通过盐敏感性遗传流行病学网络（GenSalt）随访研究，探讨Nox相关基因与纵向血压（BP）变化和高血压发生风险的关系。来自633个家庭的1768名参与者被纳入我们的分析。在早上基线和两次随访期间获得了9次血压测量。采用混合效应模型研究了11个Nox相关基因中52个标记单核苷酸多态性与血压变化和高血压的关系。基于基因的分析采用截断产物法（TPM）和通用基因关联研究（VEGAS）。在7.2年的随访中，收缩压（SBP）和舒张压（DBP）升高，32.1%（512）的参与者出现高血压。NCF2中的snp rs12094228、rs16861188和rs12066019与SBP的纵向变化显著相关（p互作分别为1.1 × 10−3、2.8 × 10−3和1.2 × 10−3）。基于基因的分析显示，NCF2与收缩压（PTPM = 1.00 × 10−6,PVEGAS = 1.26 × 10−4）和DBP变化（PTPM = 5.84 × 10−4,PVEGAS = 1.04 × 10−3）显著相关。这些发现提示NCF2可能在汉族人群血压随时间变化中起重要作用。
Previous studies have indicated that reactive oxygen species produced by NADPH oxidase (Nox) are important risk factors of hypertension. The current study aims to examine the associations of Nox related genes with longitudinal blood pressure (BP) changes and the risk of incident hypertension in the Genetic Epidemiology Network of Salt Sensitivity (GenSalt) follow-up study. A total of 1,768 participants from 633 families were included in our analysis. Nine BP measurements were obtained in the morning at baseline and during two follow-up visits. The mixed-effect models were used to investigate the associations of 52 tagged single nucleotide polymorphisms in 11 Nox related genes with BP changes and incident hypertension. Gene-based analyses were performed by truncated product method (TPM) and Versatile Gene-based Association Study (VEGAS). Over the 7.2 years of follow-up, systolic BP (SBP) and diastolic BP (DBP) increased, and 32.1% (512) of participants developed hypertension. SNPs rs12094228, rs16861188 and rs12066019 in NCF2 were significantly associated with longitudinal change in SBP (Pinteraction = 1.1 × 10−3, 2.8 × 10−3 and 1.2 × 10−3, respectively). Gene-based analyses revealed that NCF2 was significantly associated with SBP (PTPM = 1.00 × 10−6, PVEGAS = 1.26 × 10−4) and DBP changes (PTPM = 5.84 × 10−4, PVEGAS = 1.04 × 10−3). These findings suggested that NCF2 may play an important role in BP changes over time in the Han Chinese population.
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影响因子：
9.8
作者：
Liu, Jimmy Z.;Mcrae, Allan F.;Macgregor, Stuart
通讯作者：
Macgregor, Stuart
影响因子：
29
作者：
Feng D;Yang C;Geurts AM;Kurth T;Liang M;Lazar J;Mattson DL;O'Connor PM;Cowley AW Jr
通讯作者：
Cowley AW Jr
影响因子：
7
作者：
Boyle AP;Hong EL;Hariharan M;Cheng Y;Schaub MA;Kasowski M;Karczewski KJ;Park J;Hitz BC;Weng S;Cherry JM;Snyder M
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Snyder M
影响因子：
30.8
作者：
de Bakker, PIW;Yelensky, R;Altshuler, D
通讯作者：
Altshuler, D
影响因子：
4.9
作者：
Moreno, Maria U.;San Jose, Gorka;Zalba, Guillermo
通讯作者：
Zalba, Guillermo