Enzymatic Metabolism of Vitamin A in Developing Vertebrate Embryos.
Enzymatic Metabolism of Vitamin A in Developing Vertebrate Embryos.
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DOI：
10.3390/nu8120812
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发表时间：
2016-12-15
期刊：
影响因子：
5.9
通讯作者：
Sandell LL
中科院分区：
文献类型：
--
作者：
Metzler MA;Sandell LL
胚胎发育是由少数信号通路协调的，其中之一是视黄酸（RA）信号通路。维生素A是脊椎动物胚胎发育所必需的，因为它是必需信号分子RA的分子前体。RA信号在发育胚胎中的水平和分布必须受到严格的调节;太多，太少或异常分布都会破坏胚胎发育。在胚胎发生过程中，RA信号的精确调节是通过参与维生素A代谢、类维生素A转运、核信号和RA catalysts的蛋白质实现的。前体维生素A转化为活性类维生素A A的可逆第一步由视黄醇脱氢酶10（RDH 10）和脱氢酶/还原酶（SDR家族）成员3（DHRS 3）介导，这两种相关的膜结合蛋白在功能上相互激活以介导视黄醇和视黄醇的相互转化。乙醇脱氢酶（ADH）酶不有助于RA生产在正常条件下，在胚胎发生。参与维生素A代谢和类风湿性关节炎的基因以组织特异性模式表达，并受到反馈调节。编码这些蛋白质的基因突变会破坏发育中胚胎中许多系统的形态发生。总之，这些观察结果表明，在脊椎动物胚胎发育过程中，维生素A代谢在调节RA信号中的重要性。
Embryonic development is orchestrated by a small number of signaling pathways, one of which is the retinoic acid (RA) signaling pathway. Vitamin A is essential for vertebrate embryonic development because it is the molecular precursor of the essential signaling molecule RA. The level and distribution of RA signaling within a developing embryo must be tightly regulated; too much, or too little, or abnormal distribution, all disrupt embryonic development. Precise regulation of RA signaling during embryogenesis is achieved by proteins involved in vitamin A metabolism, retinoid transport, nuclear signaling, and RA catabolism. The reversible first step in conversion of the precursor vitamin A to the active retinoid RA is mediated by retinol dehydrogenase 10 (RDH10) and dehydrogenase/reductase (SDR family) member 3 (DHRS3), two related membrane-bound proteins that functionally activate each other to mediate the interconversion of retinol and retinal. Alcohol dehydrogenase (ADH) enzymes do not contribute to RA production under normal conditions during embryogenesis. Genes involved in vitamin A metabolism and RA catabolism are expressed in tissue-specific patterns and are subject to feedback regulation. Mutations in genes encoding these proteins disrupt morphogenesis of many systems in a developing embryo. Together these observations demonstrate the importance of vitamin A metabolism in regulating RA signaling during embryonic development in vertebrates.
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影响因子：
10.5
作者：
Abu-Abed, S;Dollé, P;Petkovich, M
通讯作者：
Petkovich, M
影响因子：
4.6
作者：
Cai, Anna Q.;Radtke, Kelly;Schilling, Thomas F.
通讯作者：
Schilling, Thomas F.
影响因子：
56.9
作者：
Bowles, J;Knight, D;Koopman, P
通讯作者：
Koopman, P
DOI：
10.1016/j.jsbmb.2005.05.005
发表时间：
2005-09-01
影响因子：
4.1
作者：
Balmer, JE;Blomhoff, R
通讯作者：
Blomhoff, R
影响因子：
2.9
作者：
Berry DC;Noy N
通讯作者：
Noy N