Combat veterans with posttraumatic stress disorder exhibit decreased habituation of the P1 midlatency auditory evoked potential
Combat veterans with posttraumatic stress disorder exhibit decreased habituation of the P1 midlatency auditory evoked potential
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DOI：
10.1016/s0024-3205(97)00688-7
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发表时间：
1997-08-29
期刊：
影响因子：
6.1
通讯作者：
GarciaRill, E
中科院分区：
文献类型：
--
作者：
Gillette, GM;Skinner, RD;GarciaRill, E
本研究采用配对刺激范式，调查P1中潜伏期听觉诱发电位在越南作战退伍军人创伤后应激障碍（PTSD）和三个对照组：酒精依赖，战斗暴露的正常人，和战斗未暴露的正常人。与每个对照组相比，PTSD受试者表现出P1电位的习惯性显著降低。PTSD组内P1潜在习惯化与PTSD再体验症状的强度显著相关，如创伤相关的噩梦和闪回。这些研究结果进行了讨论，一致的感觉门控缺陷在脑干水平的创伤后应激障碍，并进一步讨论的背景下，其他心理生理措施的创伤后应激障碍和P1潜在的结果，在精神疾病以外的创伤后应激障碍。
The current study used a paired stimulus paradigm to investigate the P1 midlatency auditory evoked potential in Vietnam combat veterans with posttraumatic stress disorder (PTSD) and three comparison groups: alcohol dependents, combat-exposed normals, and combat-unexposed normals. Compared to each comparison group, PTSD subjects exhibited significantly diminished habituation of the P1 potential. P1 potential habituation within the PTSD group, correlated significantly with intensity of PTSD reexperiencing symptoms, such as trauma-related nightmares and flashbacks. These findings are discussed as consistent with a sensory gating defect at the brainstem level in PTSD, and are further discussed in the context of other psychophysiological measures in PTSD and of P1 potential findings in psychiatric disorders other than PTSD.