Nuclear signaling from cadherin adhesion complexes.
Nuclear signaling from cadherin adhesion complexes.
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DOI：
10.1016/bs.ctdb.2014.11.018
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发表时间：
2015
影响因子：
--
通讯作者：
Gottardi CJ
中科院分区：
文献类型：
--
作者：
McCrea PD;Maher MT;Gottardi CJ
多细胞生物在进化过程中的出现促进了细胞间信号传导与粘附的结合。由于钙粘蛋白的外结构域在反式（以及顺式）中直接相互作用，跨越质膜并与多种其他实体相关联，钙粘蛋白可以实现“由外向内”或“由内向外”信号的转导。我们将重点回顾来自较大的钙粘蛋白家族的信号，这些信号向内指向细胞核，因此在基因控制或核结构功能中发挥作用。钙粘蛋白复合物的性质在很大程度上取决于钙粘蛋白的类型及其环境，我们将讨论经典钙粘蛋白与其他家族成员的一些变量。在了解各种钙粘蛋白复合物用于协调细胞-细胞粘附状态和基因表达的信号介质方面，已经取得了实质性但仍不完整的进展。钙粘蛋白细胞内结合伙伴也定位于细胞核的证据是一个主要的兴趣点。在一些模型中，连环蛋白显示出与钙粘蛋白细胞质尾部的结合减少，有利于它们参与基因控制。当结合时，钙粘蛋白可以作为核信号的化学计量竞争者。钙粘蛋白还直接或间接影响许多信号通路（如Wnt、受体酪氨酸激酶、Hippo、NFκB和JAK/STAT），使细胞-细胞接触接触到胚胎发育和组织稳态中的多种生物学结果。
The arrival of multicellularity in evolution facilitated cell–cell signaling in conjunction with adhesion. As the ectodomains of cadherins interact with each other directly in trans (as well as in cis), spanning the plasma membrane and associating with multiple other entities, cadherins enable the transduction of “outside-in” or “inside-out” signals. We focus this review on signals that originate from the larger family of cadherins that are inwardly directed to the nucleus, and thus have roles in gene control or nuclear structure–function. The nature of cadherin complexes varies considerably depending on the type of cadherin and its context, and we will address some of these variables for classical cadherins versus other family members. Substantial but still fragmentary progress has been made in understanding the signaling mediators used by varied cadherin complexes to coordinate the state of cell–cell adhesion with gene expression. Evidence that cadherin intracellular binding partners also localize to the nucleus is a major point of interest. In some models, catenins show reduced binding to cadherin cytoplasmic tails favoring their engagement in gene control. When bound, cadherins may serve as stoichiometric competitors of nuclear signals. Cadherins also directly or indirectly affect numerous signaling pathways (e.g., Wnt, receptor tyrosine kinase, Hippo, NFκB, and JAK/STAT), enabling cell–cell contacts to touch upon multiple biological outcomes in embryonic development and tissue homeostasis.
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影响因子：
3.7
作者：
Arnsdorf EJ;Tummala P;Jacobs CR
通讯作者：
Jacobs CR
DOI：
10.1083/jcb.201107021
发表时间：
2011-09-05
期刊：
The Journal of cell biology
影响因子：
--
作者：
Berndt JD;Aoyagi A;Yang P;Anastas JN;Tang L;Moon RT
通讯作者：
Moon RT
影响因子：
4
作者：
Aktary, Zackie;Kulak, Stephen;Pasdar, Manijeh
通讯作者：
Pasdar, Manijeh
影响因子：
9.2
作者：
Bennett, F. Christian;Harvey, Kieran F.
通讯作者：
Harvey, Kieran F.
影响因子：
56.9
作者：
Bilic, Josipa;Huang, Ya-Lin;Niehrs, Christof
通讯作者：
Niehrs, Christof