TRANSTHYRETIN (PREALBUMIN) IN THE PANCREAS AND SERA OF NEWLY DIAGNOSED TYPE-I (INSULIN-DEPENDENT) DIABETIC-PATIENTS
TRANSTHYRETIN (PREALBUMIN) IN THE PANCREAS AND SERA OF NEWLY DIAGNOSED TYPE-I (INSULIN-DEPENDENT) DIABETIC-PATIENTS
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DOI：
10.1210/jc.74.6.1372
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发表时间：
1992-06-01
影响因子：
5.8
通讯作者：
TARUI, S
中科院分区：
文献类型：
--
作者：
ITOH, N;HANAFUSA, T;TARUI, S
采用免疫组化和散射比浊法对10例初诊的I型糖尿病患者胰腺和血清中甲状腺素运载蛋白（TTR）进行了检测。在I型糖尿病胰腺中，胰高血糖素阳性A细胞对TTR表现出强烈的免疫反应性，其强度和分布模式与正常人相对应。形态计量学分析显示，TTR阳性的A细胞的数量与正常人没有显着差异。相反，胰岛素阳性B细胞，通常显示不均匀和弱TTR免疫反应，数量减少，只有少数残留的B细胞显示微弱的免疫反应。生长抑素细胞和胰多肽细胞TTR均为阴性。糖尿病患者血清TTR浓度明显低于正常人（P <0.005）。这些数据表明，TTR在A细胞中的合成或储存不受影响，但在B细胞中的合成或储存在I型糖尿病中受损。血清TTR降低可能是I型糖尿病代谢紊乱的特征之一。
We investigated transthyretin (TTR) in the pancreases and sera of 10 newly diagnosed type I diabetic patients by immunohistochemistry and nephelometry. In the type I diabetic pancreases, glucagon-positive A-cells showed strong immunoreactivity for TTR, the intensity and distribution pattern of which corresponded to those in normal subjects. Morphometric analysis revealed that the amount of strongly TTR-positive A-cells was not significantly different from that in normal subjects. On the contrary, insulin-positive B-cells, which normally show uneven and weak TTR immunoreactivity, decreased in number, and only a few residual B-cells showed faint immunoreactivity. Neither somatostatin cells nor pancreatic polypeptide cells were positive for TTR. The serum TTR concentration showed a significant decrease in type I diabetic patients compared with that in normal subjects (P < 0.005). These data suggest that the synthesis or storage of TTR in A-cells is not affected, but that in B-cells is impaired in type I diabetes. The decrease in serum TTR might be one of the features of metabolic disorders in type I diabetes.