Association Between Mitochondrial DNA Content in Leukocytes and Colorectal Cancer Risk

Association Between Mitochondrial DNA Content in Leukocytes and Colorectal Cancer Risk
复制标题

DOI：
10.1002/cncr.25906
复制
发表时间：
2011-07-15
期刊：
CANCER
影响因子：
6.2
通讯作者：
Xing, Jinliang
Xing, Jinliang
中科院分区：
医学1区
文献类型：
--
作者：
Qu, Falin;Liu, Xiaonan;Xing, Jinliang

文献摘要

被引文献

相似文献

背景：令人信服的流行病学证据表明线粒体的改变！ DNA（mtDNA），包括mtDNA的突变和异常含量，以肿瘤特异性方式参与多种恶性肿瘤的肿瘤发生，例如肺癌、乳腺癌和非霍奇金淋巴瘤。本研究旨在探讨外周血淋巴细胞 (PBL) 中的 mtDNA 含量是否可以用作结直肠癌 (CRC) 的风险预测因子。方法：通过实时定量聚合酶链反应测量 320 名 CRC 患者和 320 名匹配对照者的 PBL 中 mtDNA 含量。结果：作者发现，CRC 患者的 mtDNA 含量在统计学上显着高于匹配对照（中位数，1.03 vs.86；P < .001）。他们使用多元逻辑回归进一步评估了 mtDNA 含量与 CRC 风险之间的关联。通过使用对照组的中值作为分界点，他们发现，与低 mtDNA 含量相比，高 mtDNA 含量与 CRC 风险显着增加相关（调整后的比值比，2.03；95% 置信区间，1.41-2.81）。在趋势分析中，他们发现较高的 mtDNA 含量与增加的 CRC 风险之间存在统计学上显着的剂量反应关系（P 表示趋势）
BACKGROUND: Compelling epidemiological evidence indicated that alterations of mitochondria! DNA (mtDNA), including mutations and abnormal content of mtDNA, were implicated in the tumorigenesis of several malignancies in a tumor-specific manner, such as lung cancer, breast cancer, and non-Hodgkin lymphoma. This study was undertaken to investigate whether mtDNA content in peripheral blood lymphocytes (PBLs) could be used as a risk predictor for colorectal cancer (CRC). METHODS: The mtDNA content was measured by using quantitative real-time polymerase chain reaction in PBLs from 320 CRC patients and 320 matched controls. RESULTS: The authors found that CRC patients exhibited statistically significantly higher mtDNA content than matched controls (median, 1.03 vs.86; P < .001). They further assessed the association between mtDNA content and CRC risk using multivariate logistic regression. By using the median value in controls as the cutoff point, they found that, compared with low mtDNA content, high mtDNA content was associated with a significantly increased CRC risk (adjusted odds ratio, 2.03; 95% confidence interval, 1.41-2.81). In a trend analysis, they found a statistically significant dose-response relationship between higher mtDNA content and increased CRC risk (P for trend