Cognitive functioning in patients with schizophrenia and bipolar disorder: A quantitative review
Cognitive functioning in patients with schizophrenia and bipolar disorder: A quantitative review
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DOI：
10.1016/j.schres.2005.08.004
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发表时间：
2005-12-15
影响因子：
4.5
通讯作者：
Aleman, A
中科院分区：
文献类型：
--
作者：
Krabbendam, L;Arts, B;Aleman, A
目的：有证据表明，双相情感障碍的认知功能即使在愉悦状态下也可能受损，但尚不清楚这种缺陷模式是否类似于精神分裂症的缺陷。本研究旨在对有关精神分裂症和双相情感障碍认知功能的研究进行定量综述。方法：应用计算机检索MEDLINE和emocLIT数据库1985/2004-10期间的相关文献，检索词为“精神分裂症”合并“双相情感障碍”、“躁狂抑郁”或“躁狂”合并“认知”或“神经心理学”。31项研究包括：i)使用标准化和可靠的神经心理测试程序评估认知能力；ii)比较精神分裂症和双相情感障碍的成年患者；iii)报告两组患者的测试分数，或确切的p值、t值或F值；以及iv)作为一篇原创文章发表在同行评议的英文期刊上。结果：所有研究的荟萃分析表明，双相情感障碍患者的表现通常好于精神分裂症患者，但效应大小的分布显示出显著的异质性。结论：即使在临床和人口学特征匹配的情况下，双相情感障碍患者也比精神分裂症患者表现出更好的认知表现。(C)2005 Elsevier B.V.保留所有权利。
Objective: Evidence suggests that cognitive functioning in bipolar disorder may be impaired even in euthymic states, but it is unclear if the pattern of deficits is similar to the deficits found in schizophrenia. The aim of this study was to review quantitatively the studies on cognitive performance in schizophrenia and bipolar disorder.Methods: Articles for consideration were identified through a literature search in MEDLINE and PsycLIT in the period between 1985 and October 2004, using the keywords "schizophrenia" combined with "bipolar disorder", or "manic-depress*" or "manic" combined with "cogniti*" or "neuropsycholog*". Thirty-one studies were included that: i) evaluated cognitive performance using standardized and reliable neuropsychological testing procedures; ii) compared adult patients with schizophrenia and with bipolar disorder; iii) reported test scores of both patient groups, or exact p-values, t-values, or F-values; and iv) were published as an original article in a peer-reviewed English language journal.Results: Meta-analyses of all studies indicated that patients with bipolar disorder generally perform better than patients with schizophrenia, but the distribution of effect sizes showed substantial heterogeneity. Results based on a more homogeneous subset of studies that matched patient groups on clinical and demographic characteristics pointed in the same direction, with effect sizes in the moderate range.Conclusions: Patients with bipolar disorder show better cognitive performance than patients with schizophrenia, even when matched for clinical and demographic characteristics. (c) 2005 Elsevier B.V. All rights reserved.