Regulation of Irregular Neuronal Firing by Autaptic Transmission.
Regulation of Irregular Neuronal Firing by Autaptic Transmission.
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通过自动传递调节不规则神经元放电
DOI：
10.1038/srep26096
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发表时间：
2016-05-17
影响因子：
4.6
通讯作者：
Yao D
中科院分区：
文献类型：
--
作者：
Guo D;Wu S;Chen M;Perc M;Zhang Y;Ma J;Cui Y;Xu P;Xia Y;Yao D
自反馈自适应传输在调制尖峰时间不规则性中的重要性仍然知之甚少。通过使用一个生物物理模型，结合autaptic耦合，我们在这里表明，自我神经支配的神经元参与调制不规则的神经元放电，主要是通过调节突发放电的发生频率。特别是，我们发现，兴奋性和电autapses增加突发放电的发生，从而减少神经元放电规律。相反，抑制性自诱发抑制爆发性放电，因此倾向于改善神经元放电的规律性。重要的是，我们表明，这些发现是独立的个别神经元的放电特性，因此可以观察到在不同模式下运行的神经元。我们的研究结果提供了一个有见地的机械理解不同类型的autapses形状不规则的单神经元水平的发射，他们强调autaptic自我神经支配在驯服和调节神经动力学的功能重要性。
The importance of self-feedback autaptic transmission in modulating spike-time irregularity is still poorly understood. By using a biophysical model that incorporates autaptic coupling, we here show that self-innervation of neurons participates in the modulation of irregular neuronal firing, primarily by regulating the occurrence frequency of burst firing. In particular, we find that both excitatory and electrical autapses increase the occurrence of burst firing, thus reducing neuronal firing regularity. In contrast, inhibitory autapses suppress burst firing and therefore tend to improve the regularity of neuronal firing. Importantly, we show that these findings are independent of the firing properties of individual neurons and as such can be observed for neurons operating in different modes. Our results provide an insightful mechanistic understanding of how different types of autapses shape irregular firing at the single-neuron level and they highlight the functional importance of autaptic self-innervation in taming and modulating neurodynamics.