Age-related hypermethylation of the hMLH1 promoter in gastric cancers
Age-related hypermethylation of the hMLH1 promoter in gastric cancers
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DOI：
10.1002/ijc.1454
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发表时间：
2001-10-15
影响因子：
6.4
通讯作者：
Yuasa, Y
中科院分区：
文献类型：
--
作者：
Nakajima, T;Akiyama, Y;Yuasa, Y
为了确定 hMLH1 启动子的甲基化是否与年龄增加和胃癌发生有关，我们检查了 100 例胃癌中的 hMLH1 甲基化和表达。分别在 9 种和 13 种癌症中观察到 hMLH1 甲基化和异常蛋白表达。与高甲基化癌症相邻的正常和肠化组织没有表现出任何 hMLH1 甲基化，表明它可能是胃癌特有的。 hMLH1甲基化频率随着年龄的增长而显着增加。这些结果表明hMLH1甲基化在老年人胃癌发生中起重要作用。 (C) 2001 Wiley-Liss, Inc.
To determine whether methylation of the hMLH1 promoter is related to increasing age and gastric carcinogenesis, we examined hMLH1 methylation and expression in 100 gastric cancers. hMLH1 methylation and aberrant protein expression were observed in 9 and 13 cancers, respectively. Normal and intestinal metaplastic tissues adjacent to cancers with hypermethylation did not exhibit any hMLH1 methylation, indicating that it may be specific to gastric cancers. The frequency of hMLH1 methylation significantly increased with age. These results suggest that hMLH1 methylation plays an important role in gastric carcinogenesis in old people. (C) 2001 Wiley-Liss, Inc.