EXTRAADRENAL RETROPERITONEAL PARAGANGLIOMA - CLINICAL, PATHOLOGICAL, AND CT FINDINGS
EXTRAADRENAL RETROPERITONEAL PARAGANGLIOMA - CLINICAL, PATHOLOGICAL, AND CT FINDINGS
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DOI：
10.2214/ajr.155.6.2173385
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发表时间：
1990-12-01
影响因子：
5
通讯作者：
HARTMAN, DS
中科院分区：
文献类型：
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作者：
HAYES, WS;DAVIDSON, AJ;HARTMAN, DS
腹膜后副神经节瘤起源于沿着主动脉分布的与交感链相关的特殊神经嵴细胞。为了明确肾上腺外腹膜后副神经节瘤的特征性CT表现，以区别于其他腹膜后肿瘤，对28例患者的31例离散肿瘤和2例副神经节瘤病进行回顾性分析，并将其CT表现与临床和病理结果相关联。其中有 16 名男性和 12 名女性。平均年龄为 37 岁（范围：11-70 岁）。 24 名患者（86%）患有高血压。其中，所有 18 名接受生化研究的患者的儿茶酚胺水平均升高。 4 名患者 (14%) 患有恶性副神经节瘤。离散肿瘤按位置分为肾上（26%）、肾门（32%）或肾下（42%）。 CT 无法将肾上副神经节瘤与同侧肾上腺区分开来。功能性肿瘤的平均大小（7.0 cm）小于非功能性肿瘤（12.0 cm），但两组的大小重叠。较小的肿瘤比较大的肿瘤更可能是同质的并且具有明确的边缘。我们的研究结果表明，肾上腺外腹膜后副神经节瘤的功能活跃程度比以前报道的要高，并且 CT 很容易将其检测为与腹主动脉整个长度密切相关的软组织肿块。然而，没有发现副神经节瘤特有的 CT 特征。
Paragangliomas of the retroperitoneum arise from specialized neural creset cells distributed along the aorta in association with the sympathetic chain. In order to ascertain characteristic CT features of extraadrenal retroperitoneal paragangliomas to differentiate them from other retroperitoneal tumors, 31 discrete tumors and two cases of paragangliomatosis in 28 patients were reviewed retrospectively, and the CT features were correlated with clinical and pathologic findings. There were 16 men and 12 women. Average age was 37 years (range, 11-70 years). Twenty-four patients (86%) had hypertension. Of these, catecholamine levels were elevated in all 18 patients who had biochemical studies. Four patients (14%) had malignant paragangliomas. The discrete tumors were classified by location as suprarenal (26%), renal hilar (32%), or infrarenal (42%). Suprarenal paragangliomas could not be distinguished from the ipsilateral adrenal gland on CT. The average size of functional tumors was smaller (7.0 cm) than that of nonfunctional tumors (12.0 cm), but the sizes of the two groups overlapped. Smaller tumors were more likely to be homogeneous and have well-defined margins than were larger tumors. Our findings indicate that extraadrenal retroperitoneal paragangliomas are functionally active more often than previously reported and that they are readily detected by CT as soft-tissue masses closely associated with the entire length of the abdominal aorta. However, no CT feature was found that was unique for paraganglioma.