An epidemiologic study of insect allergy in children. I. Characteristics of the disease.
An epidemiologic study of insect allergy in children. I. Characteristics of the disease.
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儿童昆虫过敏的流行病学研究。
DOI：
10.1016/s0022-3476(82)80750-6
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Valentine,MD
中科院分区：
文献类型：
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作者：
Schuberth,KC;Lichtenstein,LM;Kagey-Sobotka,A;Szklo,M;Kwiterovich,KA;Valentine,MD
在研究的 235 名有昆虫叮咬过敏反应史的儿童中，59 名出现严重危及生命的全身反应，123 名出现轻微、不危及生命的全身反应，53 名出现严重的局部反应。总体男女比例为2：1。每组中大约 89% 的毒液皮肤测试呈阳性。先前的全身提取物疗法将多种昆虫毒液的毒液皮试反应性的可能性从 51% 增加到 78%。毒液皮试结果与之前过敏反应的严重程度无关。 109 名 NLTR 且毒液皮肤测试呈阳性的儿童被分入两组中的一组——毒液免疫治疗组或仅观察组。在前六个月中，治疗组的毒液特异性 IgE 抗体滴度预期增加了四倍，而观察组的平均 IgE 滴度则下降。观察组被意外螫伤的患者IgE抗体滴度出现短暂升高。两组中发生的少量意外叮咬导致的反应比最初的反应要温和。尽管基于初步数据，对于一些先前有轻微全身症状的儿童来说，毒液免疫疗法可能没有必要。
Of 235 children with a history of allergic reactions to insect stings studied, 59 had severe life-threatening systemic reactions 123 had mild, non-life-threatening systemic reactions, and 53 had large local reactions. The overall male-female ratio was 2:1. Venom skin tests were positive in approximately 89% of each group. Prior whole body extract therapy increased the likelihood of venom skin test reactivity to multiple insect venoms from 51 to 78%. Venom skin test results did not correlate with the severity of previous allergic reactions. One hundred and nine children with NLTR and positive venom skin tests were entered into one of two groups—venom immunotherapy or observation only. During the first six months the treatment group had the expected fourfold rise in venom-specific IgE antibody titers, whereas the observation group had a decline of the mean IgE titer. Patients in the observation group who were accidentally stung had a transient rise in IgE antibody titers. The small number of accidental stings which occurred in both groups resulted in reactions milder than the original reactions. Although based on preliminary data, venom immunotherapy may not be necessary for some children with previously mild systemic symptoms.