Release of oxytocin in the hypothalamic paraventricular nucleus, but not central amygdala or lateral septum in lactating residents and virgin intruders during maternal defence
Release of oxytocin in the hypothalamic paraventricular nucleus, but not central amygdala or lateral septum in lactating residents and virgin intruders during maternal defence
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DOI：
10.1016/j.neuroscience.2003.11.028
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发表时间：
2004-01-01
期刊：
影响因子：
3.3
通讯作者：
Neumann, ID
中科院分区：
文献类型：
--
作者：
Bosch, OJ;Krömer, SA;Neumann, ID
哺乳期大鼠催产素能系统和下丘脑-垂体-肾上腺轴对各种应激的神经内分泌反应减弱。在这项研究中，使用脑内微透析结合高灵敏度的放射免疫分析，我们的特点催产素（OXT）释放室旁核（PVN），中央杏仁核（CeA），和中-外侧隔（MS）之前，期间和之后的心理社会应激（母性防御试验）在处女入侵者和哺乳期居民大鼠（哺乳期第3天）。在PVN内，发现在暴露于居民期间，未侵入者的局部OXT释放显著增加（2.1倍，P
In lactating rats, the neuroendocrine responses of the oxytocinergic system and the hypothalamo-pituitary-adrenal axis to various kinds of stressors are attenuated. In this study, using intracerebral microdialysis in combination with a highly sensitive radioimmunoassay, we characterised oxytocin (OXT) release within the paraventricular nucleus (PVN), the central amygdala (CeA), and the medio-lateral septum (mS) before, during and after a psycho-social stressor (the maternal defence test) in both the virgin intruder and the lactating resident rat (day 3 of lactation). Within the PVN, local OXT release was found to increase significantly in virgin intruders during exposure to the resident (2.1-fold, P