Genomic organization of the human SPOCK gene and its chromosomal localization to 5q31
Genomic organization of the human SPOCK gene and its chromosomal localization to 5q31
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DOI：
10.1006/geno.1997.5199
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发表时间：
1998-03-15
期刊：
影响因子：
4.4
通讯作者：
Alliel, PM
中科院分区：
文献类型：
--
作者：
Charbonnier, F;Périn, JP;Alliel, PM
SPOCK，以前被鉴定为睾丸素，是一种模块化蛋白聚糖，携带软骨素和硫酸肝素糖胺聚糖侧链。整个基因组组织已经建立。SPOCK基因长度至少为70kb，由11个外显子组成：基因的前半部分明显扩大，但后半部分更紧凑。原位杂交和YAC定位独立地将SPOCK基因与5q31联系起来，5q31是一个包含大量编码生长因子、细胞因子、神经递质和激素受体的基因的区域，该基因位于IL9和EGR1基因之间，与5号染色体最小的常缺失区域相邻，(C) 1998学术出版社。
SPOCK, previously identified as testican, is a modular proteoglycan that carries both chondroitin and heparan sulfate glycosaminoglycan side chains. The overall genomic organization has been established. The SPOCK gene spans at least 70 kb and is composed of 11 exons: the first half of the gene is dramatically expanded, but the second half is more compact. In situ hybridization and YAC mapping independently linked the SPOCK gene to 5q31, a region containing an impressive number of genes encoding growth factors, cytokines, and neurotransmitter and hormone receptors, The gene is located between the IL9 and the EGR1 genes, bordering the smallest commonly deleted region of chromosome 5, (C) 1998 Academic Press.