Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals.
Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals.
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DOI：
10.1007/s10555-010-9235-2
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发表时间：
2010-09
影响因子：
9.2
通讯作者：
Aggarwal, Bharat B.
中科院分区：
文献类型：
--
作者：
Gupta, Subash C.;Kim, Ji Hye;Prasad, Sahdeo;Aggarwal, Bharat B.
大约2500年前，医学之父希波克拉底宣布：“让食物成为你的药物，让药物成为你的食物。”探索饮食与健康之间的联系今天仍在继续。例如，我们现在知道，多达35%的癌症可以通过改变饮食来预防。癌变是一个多步骤的过程，涉及肿瘤的转化、存活、增殖、侵袭、血管生成和转移，并且可能需要长达30年。与这一过程相关的途径与慢性炎症有关，慢性炎症是肿瘤进展的主要介质。人体由大约13万亿个细胞组成，几乎所有细胞在100天内都会发生翻转，这表明每分钟有7万个细胞发生凋亡。因此，细胞凋亡/细胞死亡是正常的生理过程，并且缺乏细胞凋亡导致患者死亡是罕见的。几乎90%的癌症死亡与肿瘤转移有关。我们的饮食如何预防癌症是这篇评论的重点。具体地说，我们将讨论如何营养保健品，如大蒜素，芹菜素，小檗碱，叶黄素，咖啡酸，辣椒素，儿茶素没食子酸酯，雷公藤红素，姜黄素，表没食子儿茶素没食子酸酯，非瑟酮，黄酮吡啶醇，藤黄酸，染料木素，白花丹素，槲皮素，白藜芦醇，血根碱，水飞蓟宾，萝卜硫素，紫杉醇，γ-生育三烯酚，和zerumbone，来自香料，豆类，水果，坚果和蔬菜，可以调节炎症途径，从而影响肿瘤的存活、增殖、侵袭、血管生成和转移。还将讨论由这些试剂调节的各种细胞信号传导途径。
Almost 25 centuries ago, Hippocrates, the father of medicine, proclaimed “Let food be thy medicine and medicine be thy food.” Exploring the association between diet and health continues today. For example, we now know that as many as 35% of all cancers can be prevented by dietary changes. Carcinogenesis is a multistep process involving the transformation, survival, proliferation, invasion, angiogenesis, and metastasis of the tumor and may take up to 30 years. The pathways associated with this process have been linked to chronic inflammation, a major mediator of tumor progression. The human body consists of about 13 trillion cells, almost all of which are turned over within 100 days, indicating that 70,000 cells undergo apoptosis every minute. Thus, apoptosis/cell death is a normal physiological process, and it is rare that a lack of apoptosis kills the patient. Almost 90% of all deaths due to cancer are linked to metastasis of the tumor. How our diet can prevent cancer is the focus of this review. Specifically, we will discuss how nutraceuticals, such as allicin, apigenin, berberine, butein, caffeic acid, capsaicin, catechin gallate, celastrol, curcumin, epigallocatechin gallate, fisetin, flavopiridol, gambogic acid, genistein, plumbagin, quercetin, resveratrol, sanguinarine, silibinin, sulforaphane, taxol, γ-tocotrienol, and zerumbone, derived from spices, legumes, fruits, nuts, and vegetables, can modulate inflammatory pathways and thus affect the survival, proliferation, invasion, angiogenesis, and metastasis of the tumor. Various cell signaling pathways that are modulated by these agents will also be discussed.
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作者：
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通讯作者：
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