Safety and immunogenicity of different immunization regimens of CVD 103-HgR live oral cholera vaccine in soldiers and civilians in Thailand.
Safety and immunogenicity of different immunization regimens of CVD 103-HgR live oral cholera vaccine in soldiers and civilians in Thailand.
复制标题
泰国士兵和平民CVD 103-HgR口服霍乱活疫苗不同免疫方案的安全性和免疫原性。
DOI：
10.1093/infdis/165.6.1042
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Losonsky,G
中科院分区：
文献类型：
--
作者：
Su-Arehawaratana,P;Singharaj,P;Taylor,DN;Hoge,C;Trofa,A;Kuvanont,K;Migasena,S;Pitisuttitham,P;Lim,YL;Losonsky,G
324名泰国军人和平民对口服霍乱弧菌疫苗CVD 103-HgR耐受良好。大多数接受5 × 108 cfu一次剂量，40例接受5 × 109 cfu一次或两次剂量。杀弧菌抗体（免疫力的最佳相关性）血清转换在士兵中低于平民（P<0.001）。将疫苗剂量增加到5 × 109 cfu可提高几何平均滴度（P<0.001），一周后第二次接种5 × 109 cfu对血清转换无明显影响。血清转化率与基线杀弧菌滴度呈负相关（P<0.001）。CVD 103-HgR在基线滴度≥ 1：40的大多数受试者中引起血清转换，其中平民在一次5 × 108 cfu剂量后100%，士兵在一次5 × 109 cfu剂量后79%，士兵在一次5 × 108 cfu剂量后45%。在基线滴度升高的人群中，杀弧菌抗体血清转换不是疫苗是否增强肠道免疫的敏感指标;对于这些受试者，必须使用其他指标。流行地区的研究方案应使用5 × 109 cfu单次给药。
AttenuatedVibrio choleraeoral vaccineCVD 103-HgR was well tolerated by 324 Thai soldiers and civilians. Most receiveda single 5 × 108cfu dose, while 40 each receivedone or two 5 × 109cfu doses. Vibriocidal antibody (the best correlate of immunity) seroconversion was lower in soldiers than civilians (P< .001). Increasing the vaccinedose to 5 × 109cfu raised the geometric mean titer (P< .001).Asecond 5 × 109cfu dose one weeklater did not notably increase seroconversions. Likelihood of seroconversionwas inverselycorrelated with baseline vibriocidal titer (P< .001). CVD 103-HgR caused seroconversion in most subjects with baseline titers ⩽1:40, including 100% of civilians after one 5 × 108cfu dose, 79% of soldiers after one 5 × 109cfu dose, and 45% of soldiers after one 5 × 108cfu dose. In persons with elevatedbaseline titers, vibriocidal antibody seroconversion is not a sensitive measure of whether vaccine has boosted intestinal immunity; for such subjects,other measurements must be used. Study regimens in endemic areas should use a single 5 × 109cfu dose.