Nephrotic syndrome and interstitial nephritis associated with celecoxib
Nephrotic syndrome and interstitial nephritis associated with celecoxib
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DOI：
10.1053/ajkd.2002.36349
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发表时间：
2002-11-01
影响因子：
13.2
通讯作者：
Krane, NK
中科院分区：
文献类型：
--
作者：
Alper, AB;Meleg-Smith, S;Krane, NK
众所周知，非甾体抗炎药（NSAIDs）会导致体液和电解质异常以及肾功能衰竭。非甾体抗炎药也可能引起急性过敏性间质性肾炎（AIN）和肾病综合征，其组织学病理特征与先前肾功能正常的患者的微小变化疾病一致。环氧合酶2 （COX-2）抑制剂的肾毒性潜能尚未确定，因为与肾病综合征相关的AIN尚未报道继发于COX-2抑制剂。本病例报告描述了第一例AIN与肾病综合征相关的患者接受选择性COX-2抑制剂塞来昔布治疗。
Nonsteroidal anti-inflammatory drugs (NSAIDs) are well known to cause fluid and electrolyte abnormalities and renal failure. NSAIDs also may cause an acute allergic interstitial nephritis (AIN) and the nephrotic syndrome, characterized by histologic pathology consistent with minimal change disease in patients with previously normal renal function. The nephrotoxic potential of cyclooxygenase 2 (COX-2) inhibitors has not been established because AIN associated with nephrotic syndrome has not been reported secondary to the COX-2 inhibitors. This case report describes the first case of AIN associated with nephrotic syndrome in a patient treated with the selective COX-2 inhibitor, celecoxib.