A Role for the RSC Chromatin Remodeler in Regulating Cohesion of Sister Chromatid Arms
A Role for the RSC Chromatin Remodeler in Regulating Cohesion of Sister Chromatid Arms
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DOI：
10.4161/cc.3.8.1014
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发表时间：
2004-05
期刊：
影响因子：
4.3
通讯作者：
Jian Huang;B. Laurent
中科院分区：
文献类型：
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作者：
Jian Huang;B. Laurent
染色体的精确分离对于生物体的增殖和发育至关重要。这一过程的缺陷可导致肿瘤发生和遗传性疾病。四亚基粘着蛋白复合体在染色体分离和基因组完整性中起着重要作用。最近，我们报道了粘连蛋白与着丝粒和染色体臂的关联受到ATP依赖的RSC染色质重塑复合物的差异调节。在这里，我们提出了两个模型来解释为什么细胞应该进化出着丝粒和姐妹臂凝聚的特殊机制，以及为什么RSC差异调节这些过程。
The precise segregation of chromosomes is critical for the proliferation and development of living organisms. Defects in this process can result in tumorigenesis and hereditary diseases. The four-subunit cohesin complex plays an essential role in chromosome segregation and genome integrity. Recently, we reported that the association of cohesin with centromeres and chromosome arms is differentially regulated by the ATP-dependent RSC chromatin-remodeling complex. Here, we propose two models to explain why the cell should have evolved special mechanisms for centromeric and sister arm cohesion and why RSC differentially regulates these processes.