Crossing the Vascular Wall: Common and Unique Mechanisms Exploited by Different Leukocyte Subsets during Extravasation.
Crossing the Vascular Wall: Common and Unique Mechanisms Exploited by Different Leukocyte Subsets during Extravasation.
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DOI：
10.1155/2015/946509
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发表时间：
2015
影响因子：
4.6
通讯作者：
van Buul JD
中科院分区：
文献类型：
--
作者：
Schnoor M;Alcaide P;Voisin MB;van Buul JD
白细胞外渗是炎症发生过程中必不可少的第一步。因此，更好地了解调节这一过程的关键分子可能有助于开发治疗炎症性疾病（如动脉粥样硬化或类风湿性关节炎）的新疗法。内皮粘附分子ICAM-1和VCAM-1被认为是白细胞粘附和跨内皮迁移的中心介质。这些分子与它们的白细胞整合素受体结合，在白细胞和内皮细胞内启动了几种信号通路的激活。一些这样的事件发生在所有白细胞亚群的跨内皮迁移过程中，而其他机制仅为单个白细胞亚群所知。在这里，我们分别从白细胞和内皮细胞的角度总结了目前关于白细胞外渗的调节机制的知识。具体来说，我们将重点强调特定白细胞亚群利用成功穿越内皮单层的共同和独特机制。
Leukocyte extravasation is one of the essential and first steps during the initiation of inflammation. Therefore, a better understanding of the key molecules that regulate this process may help to develop novel therapeutics for treatment of inflammation-based diseases such as atherosclerosis or rheumatoid arthritis. The endothelial adhesion molecules ICAM-1 and VCAM-1 are known as the central mediators of leukocyte adhesion to and transmigration across the endothelium. Engagement of these molecules by their leukocyte integrin receptors initiates the activation of several signaling pathways within both leukocytes and endothelium. Several of such events have been described to occur during transendothelial migration of all leukocyte subsets, whereas other mechanisms are known only for a single leukocyte subset. Here, we summarize current knowledge on regulatory mechanisms of leukocyte extravasation from a leukocyte and endothelial point of view, respectively. Specifically, we will focus on highlighting common and unique mechanisms that specific leukocyte subsets exploit to succeed in crossing endothelial monolayers.