Dietary chloride as a determinant of disordered calcium metabolism in salt-dependent hypertension.
Dietary chloride as a determinant of disordered calcium metabolism in salt-dependent hypertension.
复制标题
膳食氯化物是盐依赖性高血压中钙代谢紊乱的决定因素。
DOI：
10.1016/0024-3205(85)90387-x
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发表时间：
1985
期刊：
影响因子：
6.1
通讯作者：
MorrisJr,RC
中科院分区：
文献类型：
--
作者：
Kurtz,TW;MorrisJr,RC
在给予脱氧皮质酮(DOC)的大鼠中，最近报道发现，正常剂量的饮食氯化钠(NaCl)会导致高血压，但等摩尔量的碳酸氢钠(NaHCO3)不会导致高血压，这可能是由于这两种钠盐对钙代谢的不同影响所致。根据这一假设，我们发现，在单肾切除大鼠给予DOC：1)饮食氯化钠导致持续的高钙尿和高血压，而大约等摩尔量的NaHCO3饮食既不会引起高钙尿也不会引起高血压。2)在血压变化之前，注射氯化钠的大鼠尿钙排泄量大于注射碳酸氢钠的大鼠。3)用接近等摩尔量的NaHCO3代替膳食中的氯化钠，既纠正了高钙尿，又纠正了最初由氯化钠引起的高血压。
In rats given desoxycorticosterone (DOC), the recently reported finding that a normal amount of dietary sodium chloride (NaCl) induces hypertension but an equimolar amount of sodium bicarbonate (NaHCO3) does not, might be a consequence of the differing effects of the two sodium salts on the metabolism of calcium. In accord with this hypothesis, we have found that, in uninephrectomized rats given DOC: 1) Dietary NaCl induces persisting hypercalciuria and hypertension whereas an approximately equimolar amount of dietary NaHCO3induces neither hypercalciuria nor hypertension. 2) The urinary excretion of calcium becomes greater in rats given NaCl than in those given NaHCO3, before their blood pressures become different. 3) Replacing dietary NaCl with a near equimolar amount of dietary NaHCO3corrects both the hypercalciuria and the hypertension initially induced by NaCl.