Diagnosis and management of patients with primary biliary cirrhosis.
Diagnosis and management of patients with primary biliary cirrhosis.
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DOI：
10.1002/cld.320
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发表时间：
2014-03-01
影响因子：
--
通讯作者：
Jones, David
中科院分区：
文献类型：
--
作者：
Dyson, Jessica;Jones, David
原发性胆汁性肝硬化（PBC）现在最常被诊断为在其他方面良好的患者中识别出异常肝脏生化的评估结果。越来越多的患者在调查不明原因的疲劳后被诊断出来。胆汁淤积性瘙痒可能是某些患者的一个表现特征，偶尔患者会出现终末期肝病。在未来几年内，治疗范围和有效性的改善可能会增加早期诊断对最佳治疗的重要性。
Primary biliary cirrhosis (PBC) is now most frequently diagnosed as a result of an assessment following the identification of abnormal liver biochemistry in an otherwise well patient. An increasing number of patients are diagnosed after investigations of unexplained fatigue. Cholestatic pruritus can be a presenting feature in some, and occasional patients will present with end-stage liver disease. Improvements in the range and effectiveness of therapies over the next few years are likely to increase the importance of an early diagnosis for optimal therapy.