Too much of a good thing: The role of protein kinase CK2 in tumorigenesis and prospects for therapeutic inhibition of CK2
Too much of a good thing: The role of protein kinase CK2 in tumorigenesis and prospects for therapeutic inhibition of CK2
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DOI：
10.1016/j.bbapap.2007.08.017
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发表时间：
2008-01-01
影响因子：
3.2
通讯作者：
Litchfield, David W.
中科院分区：
文献类型：
--
作者：
Duncan, James S.;Litchfield, David W.
CK 2是一种高度保守的蛋白丝氨酸/苏氨酸激酶，其广泛分布于真核生物中，具有组成型活性，并与多种细胞功能以及肿瘤发生和转化有关。CK 2活性升高与几种组织的恶性转化有关，并与侵袭性肿瘤行为有关。虽然CK 2在肿瘤发生中的确切作用仍不完全清楚，但越来越多的证据表明CK 2通过调节肿瘤抑制因子和癌基因活性在保护细胞免于凋亡中发挥作用。因此，CK 2已成为潜在的治疗靶点，抑制CK 2的策略已在临床前试验中进行。本综述将重点关注已发表的证据，突出CK 2在促进肿瘤发生中发挥作用的分子机制，以及审查目前用于抑制CK 2的策略。(C)2007 Elsevier B. V.保留所有权利。
CK2 is a highly conserved protein serine/threonine kinase that is ubiquitously distributed in eukaryotes, constitutively active and has been implicated in multiple cellular functions, as well as in tumorigenesis and transformation. Elevated CK2 activity has been associated with the malignant transfort-nation of several tissues and is associated with aggressive tumor behaviour. While the precise roles of CK2 in tumorigenesis remain incompletely understood, mounting evidence suggests a role for CK2 in the protection of cells from apoptosis via the regulation of tumor suppressor and oncogene activity. Consequently, CK2 has emerged as a potential therapeutic target, and strategies to inhibit CK2 have been ongoing in pre-clinical trials. This review will focus on published evidence highlighting the molecular mechanisms by which CK2 functions in the promotion of tumorigenesis, as well as review current strategies being used to inhibit CK2. (C) 2007 Elsevier B.V. All rights reserved.