Injectable calcium phosphate cement: Effects of powder-to-liquid ratio and needle size
Injectable calcium phosphate cement: Effects of powder-to-liquid ratio and needle size
复制标题
DOI：
10.1002/jbm.b.30896
复制
发表时间：
2008-02-01
影响因子：
3.4
通讯作者：
Sun, Limin
中科院分区：
文献类型：
--
作者：
Burguera, Elena F.;Xu, Hockin H. K.;Sun, Limin
磷酸钙骨水泥（CPC）在原位固化形成具有良好骨传导性和骨替代能力的磷灰石。本研究的目的是制备一种可注射的磷酸四钙-磷酸二钙骨水泥（CPCD），并研究粉液比和针径的影响。挤出糊剂的注射力（平均值+/- SD; n = 4）从使用10号针头的（8 +/- 2）N增加到使用2.1号针头的（144 +/- 17）N（p < 0.05）。使用10号针头，在粉末/液体比为3时，挤出糊剂的质量百分比为（95 +/-4）%;在粉末/液体= 3.5时，其降低至（70 +/-12）%（p < 0.05）。建立了注射力F和针腔横截面积A之间的关系：F = 5.0 + 38.7/A（0.8）。抗弯强度S（平均值+/- SD; n = 5）从粉末/液体= 2时的（5.3 +/- 0.8）MPa增加到粉末/液体= 3.5时的（11.0 +/- 0.8）MPa（p < 0.05）。孔隙体积分数P的范围为62.4%至47.9%。建立了相关性：S = 47.7 x（1 - P）（2.3）。可注射CPCD的强度匹配/超过了所报告的需要机加工的烧结多孔羟基磷灰石植入物的强度。具有相对高强度的新型可注射CPCD可用于填充具有有限可及性的缺陷，例如牙周修复和牙根管填充，以及用于微创技术，例如经皮椎体成形术，以填充病变并强化骨质疏松骨。(C)2007 Wiley Periodicals，Inc.
Calcium phosphate cement (CPC) sets in situ and forms apatite with excellent osteoconductivity and bone-replacement capability. The objectives of this study were to formulate an injectable tetracalcium phosphate-dicalcium phosphate cement (CPCD), and investigate the powder/liquid ratio and needle-size effects. The injection force (mean +/- SD; n = 4) to extrude the paste increased from (8 +/- 2) N using a 10-gauge needle to (144 +/- 17) N using a 2.1-gauge needle (p < 0.05). With the 10-gauge needle, the mass percentage of extruded paste was (95 +/- 4)% at a powder/liquid ratio of 3; it decreased to (70 +/- 12)% at powder/liquid = 3.5 (p < 0.05). A relationship was established between injection force, F, and needle lumen cross-sectional area, A: F = 5.0 + 38.7/A(0.8). Flexural strength, S, (mean +/- SD; n = 5) increased from (5.3 +/- 0.8) MPa at powder/liquid = 2 to (11.0 +/- 0.8) MPa at powder/liquid = 3.5 (p < 0.05). Pore volume fraction, P, ranged from 62.4% to 47.9%. A relationship was established: S = 47.7 x (1 - P)(2.3). The strength of the injectable CPCD matched/exceeded the reported strengths of sintered porous hydroxyapatite implants that required machining. The novel injectable CPCD with a relatively high strength may be useful in filling defects with limited accessibility such as periodontal repair and tooth root-canal fillings, and in minimally-invasive techniques such as percutaneous vertebroplasty to fill the lesions and to strengthen the osteoporotic bone. (C) 2007 Wiley Periodicals, Inc.