Platelet activation status in the diagnosis and postoperative prognosis of hepatocellular carcinoma.
Platelet activation status in the diagnosis and postoperative prognosis of hepatocellular carcinoma.
复制标题
血小板活化状态在肝细胞癌诊断及术后预后中的作用
DOI：
10.1016/j.cca.2019.03.1634
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发表时间：
2019-08
影响因子：
5
通讯作者：
Cheng Yunfeng
中科院分区：
文献类型：
--
作者：
Wang Beili;Zhu Jie;Ma Xiaolu;Wang Hao;Qiu Shuangjian;Pan Baishen;Zhou Jian;Fan Jia;Yang Xinrong;Guo Wei;Cheng Yunfeng
背景静脉血栓栓塞可能是由血小板活化增加引起的，是肿瘤预后的危险因素。我们通过测定血小板活化状态来诊断肝细胞癌并预测术后预后。方法我们对2016年4月至2016年7月中山医院诊断为HCC的191例患者以及99例健康人进行前瞻性研究。使用流式细胞术通过 2 种血小板标记物 PAC-1 和 CD62p 评估血小板活化状态。患者接受TACE或切除治疗并监测≥6个月。通过受试者工作特征曲线确定标记物阳性血小板的诊断价值，并采用Kaplan-Meier法和COX回归模型分析术后价值。结果标记物阳性血小板水平高的3组均可能诊断为HCC，且PAC-1+百分比疗效最佳。单因素分析显示PAC-1+和CD62p+血小板水平是TACE和切除术后预后不良的危险因素。此外，多因素分析显示PAC-1+血小板水平是预后不良的独立危险因素。结论PAC-1+血小板百分比是诊断和预测术后预后的新指标。
BackgroundThe venous thromboembolism, which may be caused by increased platelet activation, is a risk factor for tumor prognosis. We determined the platelet activation status for diagnosis and predicting postoperative prognosis of hepatocellular carcinoma.MethodsWe conducted a prospective study of 191 patients diagnosed with HCC at Zhongshan Hospital from April 2016 to July 2016 as well as 99 healthy people. The platelet activation status was assessed by 2 platelet markers, PAC-1 and CD62p, using flow cytometry. The patients were treated with TACE or resection and monitored for ≥6 months. The diagnostic value of marker-positive platelets was determined by the receiver operating characteristic curve and the postoperative value were analyzed using the Kaplan-Meier method and COX regression model.ResultsAll the 3 groups with high levels of marker-positive platelets were likely to be diagnosed with HCC and the PAC-1+percentage had the best efficacy. The univariate analysis showed that the levels of PAC-1+and CD62p+platelets was risker factors for poor postoperative prognosis after both TACE and resection. Moreover, the multivariate analysis revealed that the level of PAC-1+platelets was an independent risk factor for poor prognosis.ConclusionsThe PAC-1+percentage of platelets is a new indicator for diagnosis and predicting postoperative prognosis.
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影响因子：
81.5
作者：
Llovet, Josep M.;Zucman-Rossi, Jessica;Gores, Gregory
通讯作者：
Gores, Gregory
影响因子：
1.5
作者：
Gilles, HoChong;Garbutt, Tonora;Landrum, Jasmine
通讯作者：
Landrum, Jasmine
DOI：
10.1073/pnas.94.2.663
发表时间：
1997-01-21
影响因子：
11.1
作者：
Mohle, R;Green, D;Rafii, S
通讯作者：
Rafii, S
DOI：
10.1007/s00104-022-01661-4
发表时间：
2022-07-01
期刊：
CHIRURGIE
影响因子：
--
作者：
Braun, Felix;Schaefer, Jost Philipp;Linecker, Michael
通讯作者：
Linecker, Michael
影响因子：
2.5
作者：
Marrero, JA
通讯作者：
Marrero, JA