SAFETY EVALUATION OF SELENIUM SULFIDE ANTIDANDRUFF SHAMPOOS
SAFETY EVALUATION OF SELENIUM SULFIDE ANTIDANDRUFF SHAMPOOS
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DOI：
10.1016/0041-008x(71)90092-5
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发表时间：
1971-01-01
影响因子：
3.8
通讯作者：
KIMURA, ET
中科院分区：
文献类型：
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作者：
CUMMINS, LM;KIMURA, ET
据文献记载，各种硒化合物具有高度毒性。然而，应该指出的是，也有某些离子形式的硒，口服时没有毒性。一种这样的化合物是不溶于水的硫化硒（SeS 2）。因此，进行了研究，以提供以下数据来支持硫化硒和含硫化硒洗发剂的安全性：（1）硫化硒（SeS 2）不应被归类为与高毒性亚硒酸钠相同的毒性类别，因为SeS 2的毒性低20倍;（2）SeS_2与其他主要去屑洗发水活性成分的大鼠经口LD_（50）值比较表明，SeS_2应归类为与其他活性成分相同的毒性类别。(3)1%和2.5%SeS 2洗发剂的口服LD 50值约为催吐剂量的10倍，因此表明摄入有毒量的洗发剂不可能不发生呕吐;和（4）狗口服1%SeS 2制剂表明基本上没有吸收，这由缺乏增加的硒血液水平所表明。
It is well documented that various selenium compounds are highly toxic. However, it should be pointed out that there are also certain ionic forms of selenium that are not as toxic when taken orally. One such compound is the water-insoluble selenium sulfide (SeS2). Studies were conducted, therefore, to present the following data to support the safety of selenium sulfide and the selenium sulfide-containing shampoos: (1) selenium sulfide (SeS2) should not be classified in the same toxicity category as the highly toxic sodium selenite, since SeS2is 20 times less toxic; (2) comparative oral LD50 values in rats of SeS2and active components from other leading antidandruff shampoos indicate that SeS2should be classified in the same toxicity category as these other active ingredients. (3) the oral LD50 values for 1% and 2.5% SeS2shampoos are about 10 times the emetic doses, thus suggesting that a toxic amount of shampoo could not be ingested without emesis occurring; and (4) oral dosing of a 1% SeS2formulation to dogs indicates essentially no absorption as indicated by the lack of an increased selenium blood level.