The hypersensitive response; the centenary is upon us but how much do we know?
The hypersensitive response; the centenary is upon us but how much do we know?
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DOI：
10.1093/jxb/erm239
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发表时间：
2008-02-01
影响因子：
6.9
通讯作者：
Prats, Elena
中科院分区：
文献类型：
--
作者：
Mur, Luis A. J.;Kenton, Paul;Prats, Elena
随着病原体挑战后对“超敏反应”的首次描述的一百周年，评估我们目前对细胞死亡的超敏反应（HR）形式的理解是合适的。近几十年来，我们的理解的启动，相关的信号，和一些重要的蛋白水解事件与HR已显着增加。遗传学方法越来越多地阐明HR起始抗性基因的功能，并且已经对死亡相关信号、钙、活性氧（ROS）、一氧化氮、水杨酸和现在的鞘脂进行了广泛的分析。与此同时，试图将哺乳动物细胞凋亡与HR之间的相似之处联系起来的尝试在很大程度上是不成功的，最好将HR视为植物细胞死亡的一种独特形式。我们将考虑HR形式的细胞死亡是否可能通过代谢功能障碍发生，其中细胞器功能障碍可能起主要作用。这次审查将强调，虽然我们的知识的HR的部分是优秀的，一个全面的分子模型仍有待实现。
With the centenary of the first descriptions of 'hypersensitiveness' following pathogenic challenge upon us, it is appropriate to assess our current understanding of the hypersensitive response (HR) form of cell death. In recent decades our understanding of the initiation, associated signalling, and some important proteolytic events linked to the HR has dramatically increased. Genetic approaches are increasingly elucidating the function of the HR initiating resistance genes and there have been extensive analyses of death-associated signals, calcium, reactive oxygen species (ROS), nitric oxide, salicylic acid, and now sphingolipids. At the same time, attempts to draw parallels between mammalian apoptosis and the HR have been largely unsuccessful and it may be better to consider the HR to be a distinctive form of plant cell death. We will consider if the HR form of cell death may occur through metabolic dysfunction in which malfunctioning organelles may play a major role. This review will highlight that although our knowledge of parts of the HR is excellent, a comprehensive molecular model is still to be attained.