Utility of intracerebral theta burst electrical stimulation to attenuate interhemispheric inhibition and to promote motor recovery after cortical injury in an animal model
Utility of intracerebral theta burst electrical stimulation to attenuate interhemispheric inhibition and to promote motor recovery after cortical injury in an animal model
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DOI：
10.1016/j.expneurol.2014.05.023
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发表时间：
2014-11-01
影响因子：
5.3
通讯作者：
Reynolds, John N. J.
中科院分区：
文献类型：
--
作者：
Barry, Melissa D.;Boddington, Laura J.;Reynolds, John N. J.
中风等大脑皮层损伤后，损伤核心周围的过度抑制被认为会降低新运动学习的潜力。部分原因可能是大脑半球间抑制（IHI）失衡所致；因此，缓解从健康半球到病灶周围区域的抑制驱动的治疗可能会增强运动恢复。经颅磁刺激传递的 Theta 突发刺激已被测试为 IHI 正常化的一种手段，但临床结果各不相同。在这里，我们使用一种新的突触 IHI 大鼠模型来证明颅内电波刺激会导致运动皮层兴奋性的持久变化。此外，我们还发现对侧间歇性 θ 爆发刺激 (iTBS) 通过涉及大麻素受体的机制阻断 IHI。最后，我们表明，在大鼠皮质损伤恢复过程中应用对侧 iTBS 可改善运动功能的恢复。这些发现表明，通过植入电极传递的θ爆发刺激可能是探索增强脑损伤康复的有希望的途径。 (C) 2014 Elsevier Inc. 保留所有权利。
Following a cerebral cortex injury such as stroke, excessive inhibition around the core of the injury is thought to reduce the potential for new motor learning. In part, this may be caused by an imbalance of interhemispheric inhibition (IHI); therefore, treatments that relieve the inhibitory drive from the healthy hemisphere to the peri-lesional area may enhance motor recovery. Theta burst stimulation delivered by transcranial magnetic stimulation has been tested as a means of normalizing IHI, but clinical results have been variable. Here we use a new rat model of synaptic IHI to demonstrate that electrical intracranial theta burst stimulation causes long-lasting changes in motor cortex excitability. Further, we show that contralateral intermittent theta burst stimulation (iTBS) blocks IHI via a mechanism involving cannabinoid receptors. Finally, we show that contralesional iTBS applied during recovery from cortical injury in rats improves the recovery of motor function. These findings suggest that theta burst stimulation delivered through implanted electrodes may be a promising avenue to explore for augmenting rehabilitation from brain injury. (C) 2014 Elsevier Inc. All rights reserved.