Cell death in the mammalian visual system during normal development: I. Retinal ganglion cells
Cell death in the mammalian visual system during normal development: I. Retinal ganglion cells
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正常发育过程中哺乳动物视觉系统的细胞死亡：I. 视网膜神经节细胞
DOI：
10.1002/cne.902040402
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发表时间：
1982
影响因子：
2.5
通讯作者：
B. Finlay
中科院分区：
文献类型：
--
作者：
D. Sengelaub;B. Finlay
在仓鼠出生后早期发育的视网膜神经节细胞层，可用光学显微镜观察到变性细胞。出生后第一天，每1000个活细胞中有2.7个细胞退化。这一比率在出生后第5天上升到每1000个活细胞中14.7个变性细胞的峰值，然后在出生后第10天放缓到每1000个活细胞中有4.2个细胞死亡。这些细胞死亡率相当于神经节细胞层中的细胞数量减少了49%。对细胞死亡的空间模式的检查表明，尽管肉眼观察到退化的细胞似乎成团出现，但统计分析表明，视网膜区域内存在随机分布。在整个视网膜中，外围视网膜的细胞死亡率高于中央视网膜。观察到的时间和模式与视网膜投射的主要靶点上丘浅层的细胞变性很好地一致。
Degenerating cells may be observed with light microscopy in the hamster retinal ganglion cell layer during early postnatal development. On the first postnatal day, degenerating cell profiles were found at a rate of 2.7 per 1,000 live cells. This rate increased to a peak of 14.7 degenerating cells per 1,000 live on postnatal day 5 and then slowed to 4.2 per 1,000 live by postnatal day 10. These rates of cell death correspond to a 49% reduction in cell number in the ganglion cell layer. Examination of the spatial pattern of cell death revealed that although on visual inspection degenerating cells appear to occur in clumps, statistical analyses demonstrated a random distribution within retinal areas. Across the retina, cell death rates were higher in peripheral retina than in central retina. The timing and pattern observed correspond well with that of cell degeneration observed in the superficial layers of the superior colliculus, the major target of the retinal projection.