Myopia-related stepwise and quadrant retinal microvascular alteration and its correlation with axial length
Myopia-related stepwise and quadrant retinal microvascular alteration and its correlation with axial length
复制标题
近视相关的阶梯式和象限性视网膜微血管改变及其与眼轴长度的相关性
DOI：
10.1038/s41433-020-01225-y
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发表时间：
2020-10-21
期刊：
影响因子：
3.9
通讯作者：
Ke, Bilian
中科院分区：
文献类型：
--
作者：
Liu, Mingming;Wang, Peng;Ke, Bilian
目的探讨不同程度近视患者视网膜血管改变的特点，确定不同视网膜区域视网膜血管改变的相关变量和改变模式。用光学相干断层血管成像(OCTA)对视网膜浅层、深层和全层的黄斑血管进行成像。使用定制软件将整个环状区、四个象限和六个环状区的血管密度量化为分维。结果轻度近视组视网膜浅层、深层和全层微血管密度最高，中度近视组次之，高度近视组次之，高度近视组最低。在同一层内，任意两组之间的差异均有统计学意义( 均为0.05)。在四个象限中，只有下鼻(IN)象限的微血管密度在轻度和中度组之间没有差异。岭回归分析显示，视网膜微血管密度与眼轴长度(−0.139，−0.103，−0.154；Alp<； 0.001)的相关性均高于与球面等效值(Scaled Estiments−0.052，−0.096，−0.057；ALLP<； 0.057)的相关性。结论视网膜微血管密度呈从轻度近视到高度近视的阶梯式象限变化，受眼轴延长的影响更大，但AL和SE都是有意义的指标。
PurposeTo investigate the characteristics of retinal vascular alterations in patients with varying degrees of myopia, and to determine correlated variables and alteration patterns over different retinal zones.MethodsA total of 208 right eyes of 208 patients with myopia were enrolled and divided into mild, moderate, high, and extreme myopia groups. The macular vasculature in superficial, deep, and whole retinal layers was imaged with optical coherence tomography angiography (OCTA). The vessel densities over the whole annular zone, four quadrants, and six annuli were quantified as fractal dimension using a customized software. Simple linear regressions and ridge regression were used to determine and compare explanatory variables of microvascular density.ResultsThe microvascular density within the superficial, deep and whole retinal layers was highest in mild myopia group, second highest in moderate myopia group, second lowest in high myopia group and lowest in extreme myopia group. Within the same layer, differences between any two groups were significant (allp< 0.05). Among the four quadrants, only the inferior nasal (IN) quadrant showed no difference in microvascular density between mild and moderate groups. Ridge regression indicated that microvascular density values in all three layers were more strongly correlated with axial length (AL) (scaled estimates −0.139, −0.103, −0.154; allp< 0.001) than with spherical equivalent (SE) (scaled estimates −0.052, −0.096, −0.057; allp< 0.05).ConclusionsWe characterized a stepwise and quadrant alteration of retinal microvascular density from mild to extreme myopia, which was more strongly affected by axial elongation, although both AL and SE were meaningful indicators.