Guanine nucleotide-binding and autophosphorylating activities associated with the p21src protein of Harvey murine sarcoma virus
Guanine nucleotide-binding and autophosphorylating activities associated with the p21src protein of Harvey murine sarcoma virus
复制标题
与哈维鼠肉瘤病毒 p21src 蛋白相关的鸟嘌呤核苷酸结合和自磷酸化活性
作者：
T. Y. Shih;A. Papageorge;P. E. Stokes;M. Weeks;E. Scolnick
纯化的哈维肉瘤病毒p21src蛋白显示出鸟嘌呤核苷酸结合活性，此外，在高温下，在苏氨酸残基上有自磷酸化活性，作为磷酸基供体GTP或dGTP，而不是ATP或dATP。这些生物化学活动在与含rna或含dna肿瘤病毒的转化蛋白相关的生物化学活动中是独一无二的。
The purified p21src protein of Harvey sarcoma virus shows a guanine nucleotide-binding activity and, in addition, at elevated temperature an autophosphorylating activity at a threonine residue using as phosphoryl donor GTP or dGTP but not ATP or dATP. These biochemical activities are unique among those associated with transforming proteins of RNA-containing or DNA-containing tumour viruses.