Cinnamon treatment upregulates neuroprotective proteins Parkin and DJ-1 and protects dopaminergic neurons in a mouse model of Parkinson's disease.
Cinnamon treatment upregulates neuroprotective proteins Parkin and DJ-1 and protects dopaminergic neurons in a mouse model of Parkinson's disease.
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DOI：
10.1007/s11481-014-9552-2
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发表时间：
2014-09
影响因子：
6.2
通讯作者：
Pahan, Kalipada
中科院分区：
文献类型：
--
作者：
Khasnavis, Saurabh;Pahan, Kalipada
神经退行性损伤期间星形胶质细胞中帕金森病（PD）相关有益蛋白（例如Parkin和DJ-1）的上调和/或维持可能对PD具有治疗功效。肉桂是世界上常用的天然香料和调味料。在这里，我们探索了肉桂在上调Parkin和DJ-1以及保护MPTP小鼠PD模型中的多巴胺能神经元中的新用途。最近，我们已经描绘了口服肉桂（肉桂）粉产生苯甲酸钠（NaB）在小鼠的血液和脑中。促炎细胞因子IL-1β降低小鼠星形胶质细胞中Parkin/DJ-1的水平。然而，肉桂代谢物NaB消除了IL-1β诱导的这些蛋白质的丢失。TNF-α不能产生一氧化氮（NO）并降低野生型（WT）星形胶质细胞中Parkin/DJ-1的水平，IL-1β不能降低从iNOS（−/−）小鼠分离的星形胶质细胞中的Parkin/DJ-1，以及NO供体NONOate降低WT星形胶质细胞中的Parkin/DJ-1，表明NO是Parkin/DJ-1的负调节剂。此外，NaB对星形胶质细胞中IL-1β诱导的iNOS表达的抑制和NaB介导的Parkin/DJ-1保护作用在星形胶质细胞中被α-NONOate逆转表明，NaB通过抑制iNOS保护活化星形胶质细胞中的Parkin/DJ-1。同样，MPTP中毒也增加了黑质中iNOS的水平，并降低了体内Parkin/DJ-1的水平。然而，口服肉桂粉和NaB的MPTP中毒小鼠的黑质中的iNOS的表达和保护Parkin/DJ-1的减少。这些发现证实了肉桂对MPTP中毒小鼠多巴胺能神经元的保护作用，使纹状体神经递质正常化，并改善了运动功能。这些结果表明，肉桂可能对PD患者有益。
Upregulation and/or maintenance of Parkinson’s disease (PD)-related beneficial proteins such as Parkin and DJ-1 in astrocytes during neurodegenerative insults may have therapeutic efficacy in PD. Cinnamon is a commonly used natural spice and flavoring material throughout the world. Here we have explored a novel use of cinnamon in upregulating Parkin and DJ-1 and protecting dopaminergic neurons in MPTP mouse model of PD. Recently we have delineated that oral feeding of cinnamon (Cinnamonum verum) powder produces sodium benzoate (NaB) in blood and brain of mice. Proinflammatory cytokine IL-1β decreased the level of Parkin/DJ-1 in mouse astrocytes. However, cinnamon metabolite NaB abrogated IL-1β-induced loss of these proteins. Inability of TNF-α to produce nitric oxide (NO) and decrease the level of Parkin/DJ-1 in wild type (WT) astrocytes, failure of IL-1β to reduce Parkin/DJ-1 in astrocytes isolated from iNOS (−/−) mice, and decrease in Parkin/DJ-1 in WT astrocytes by NO donor DETA-NONOate suggest that NO is a negative regulator of Parkin/DJ-1. Furthermore, suppression of IL-1β-induced expression of iNOS in astrocytes by NaB and reversal of NaB-mediated protection of Parkin/DJ-1 by DETA-NONOate in astrocytes indicate that NaB protects Parkin/DJ-1 in activated astrocytes via suppressing iNOS. Similarly MPTP intoxication also increased the level of iNOS and decreased the level of Parkin/DJ-1 in vivo in the nigra. However, oral treatment of MPTP-intoxicated mice with cinnamon powder and NaB reduced the expression of iNOS and protected Parkin/DJ-1 in the nigra. These findings paralleled dopaminergic neuronal protection, normalized striatal neurotransmitters, and improved motor functions by cinnamon in MPTP-intoxicated mice. These results suggest that cinnamon may be beneficial for PD patients.
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影响因子：
6.2
作者：
Jana, Arundhati;Modi, Khushbu K.;Roy, Avik;Anderson, John A.;van Breemen, Richard B.;Pahan, Kalipada
通讯作者：
Pahan, Kalipada
影响因子：
4.4
作者：
Jana, Malabendu;Jana, Arundhati;Pahan, Kalipada
通讯作者：
Pahan, Kalipada
DOI：
10.1073/pnas.0400569101
发表时间：
2004-06-22
影响因子：
11.1
作者：
Benner, EJ;Mosley, RL;Gendelman, HE
通讯作者：
Gendelman, HE
DOI：
10.1523/jneurosci.4144-09.2009
发表时间：
2009-10-28
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Ghosh A;Roy A;Matras J;Brahmachari S;Gendelman HE;Pahan K
通讯作者：
Pahan K
影响因子：
6.2
作者：
Mondal, Susanta;Roy, Avik;Jana, Arundhati;Ghosh, Sankar;Kordower, Jeffrey H.;Pahan, Kalipada
通讯作者：
Pahan, Kalipada