The Effect of Altitude-Induced Hypoxia on Heart Disease: Do Acute, Intermittent, and Chronic Exposures Provide Cardioprotection?
The Effect of Altitude-Induced Hypoxia on Heart Disease: Do Acute, Intermittent, and Chronic Exposures Provide Cardioprotection?
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DOI：
10.1089/ham.2010.1021
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发表时间：
2011-04-01
影响因子：
2.1
通讯作者：
Honigman, Benjamin
中科院分区：
文献类型：
--
作者：
Anderson, John D.;Honigman, Benjamin
安德森、约翰·D.和本杰明·霍尼根。高原引起的缺氧对心脏病的影响：急性、间歇性和慢性暴露是否能提供心脏保护作用？高Alt。医学生物学。 12:45-55, 2011.-随着全球心脏病患病率持续增加以及世界各地大量人口生活在高原地区，我们回顾了高原和心脏保护的概念。讨论了当前的流行病学数据，以及涉及急性、间歇性和慢性高原暴露的基础科学和分子机制。间歇性和慢性暴露已被证明可以增加冠状动脉血管系统，减少梗塞面积，并提供更有效的新陈代谢和更好的缺血后心脏功能恢复。在这些情况下证明的机制包括由缺氧诱导因子以及活性氧、某些离子通道和蛋白激酶介导的机制。尽管由于许多混杂因素，目前的流行病学研究很难解释，但许多研究指出，生活在高原地区可能提供心血管保护。需要进一步的研究来确定基准研究显示的与心脏保护一致的机制是否适用于生活在高海拔地区的人群。
Anderson, John D., and Benjamin Honigan. The effect of altitude-induced hypoxia on heart disease: do acute, intermittent, and chronic exposures provide cardioprotection? High Alt. Med Biol. 12:45-55, 2011.-With the global prevalence of heart disease continuing to increase and large populations living at altitude around the world, we review the concept of altitude and cardioprotection. Current epidemiologic data, as well as the basic science and molecular mechanisms involved in acute, intermittent, and chronic exposure to altitude, are discussed. Intermittent and chronic exposures have been demonstrated to increase coronary vasculature, decrease infarction size, and provide more efficient metabolism and better cardiac functional recovery postischemia. Mechanisms demonstrated in these situations include those mediated by the hypoxia inducible factor, as well as reactive oxygen species, certain ion channels, and protein kinases. Although current epidemiologic studies are difficult to interpret owing to many confounders, many studies point to the possibility that living at altitude provides cardiovascular protection. Further research is needed to determine if the bench studies showing mechanisms consistent with cardioprotection translate to the population living at altitude.