Tumor evasion from T cell surveillance.
Tumor evasion from T cell surveillance.
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DOI：
10.1155/2011/918471
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发表时间：
2011
影响因子：
--
通讯作者：
Temme A
中科院分区：
文献类型：
--
作者：
Töpfer K;Kempe S;Müller N;Schmitz M;Bachmann M;Cartellieri M;Schackert G;Temme A
一个完整的免疫系统是必不可少的，以防止肿瘤细胞的发展和进展的过程中称为免疫监视。在此过程中，先天性和适应性免疫系统密切合作，特别是T细胞在检测和消除肿瘤细胞方面发挥重要作用。由于中枢耐受的机制，展示适当排列的肿瘤肽特异性T细胞受体的T细胞的频率非常低，并且它们被专职抗原呈递细胞（例如树突状细胞）激活经常受到导致外周耐受的不足共刺激的阻碍。此外，抑制性免疫回路可损害反应性T细胞的有效抗肿瘤应答。还已经证明，大的肿瘤负荷可以促进免疫抑制状态，这反过来可以促进肿瘤进展。此外，大多数遗传不稳定的肿瘤细胞可以获得进一步损害T细胞免疫监视的拯救机制。在此，我们总结了肿瘤细胞如何逃避T细胞免疫监视的数据，重点是实体瘤，并描述了提高T细胞抗癌能力的方法。
An intact immune system is essential to prevent the development and progression of neoplastic cells in a process termed immune surveillance. During this process the innate and the adaptive immune systems closely cooperate and especially T cells play an important role to detect and eliminate tumor cells. Due to the mechanism of central tolerance the frequency of T cells displaying appropriate arranged tumor-peptide-specific-T-cell receptors is very low and their activation by professional antigen-presenting cells, such as dendritic cells, is frequently hampered by insufficient costimulation resulting in peripheral tolerance. In addition, inhibitory immune circuits can impair an efficient antitumoral response of reactive T cells. It also has been demonstrated that large tumor burden can promote a state of immunosuppression that in turn can facilitate neoplastic progression. Moreover, tumor cells, which mostly are genetically instable, can gain rescue mechanisms which further impair immune surveillance by T cells. Herein, we summarize the data on how tumor cells evade T-cell immune surveillance with the focus on solid tumors and describe approaches to improve anticancer capacity of T cells.
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影响因子：
4.4
作者：
Chung, CD;Patel, VP;Miceli, MC
通讯作者：
Miceli, MC
影响因子：
4.4
作者：
Chemnitz, JM;Parry, RV;Riley, JL
通讯作者：
Riley, JL
影响因子：
3.9
作者：
Blansfield, JA;Beck, KE;Sherry, RM
通讯作者：
Sherry, RM
DOI：
10.1073/pnas.91.11.4751
发表时间：
1994-05-24
影响因子：
11.1
作者：
BICKNELL, DC;ROWAN, A;BODMER, WF
通讯作者：
BODMER, WF
影响因子：
11.2
作者：
Blank, C;Brown, I;Gajewski, TF
通讯作者：
Gajewski, TF